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IRCT201610174731N15 IRCT 2017-01-20 Tabriz Medical University The effect of Dexmethomedin on oxygenation The effect of Dexmethomedin on oxygenation in patients with one lung ventilation during thracic srugery 2016-08-22 anticipated 42 Complete https://irct.ir/trial/5056 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomly permuted blocks method used for patients randomized assignment to study groups. 2-3 Drug effect on lung ventilation. Intervention 1: control group: 1 microgram per kilogram body weight, dexmetedomidine will be given during first 10 minutes after anesthesia and infusion will be administered in dosage of 0.9 microgram per kilogram body weight during per hour. Intervention 2: control group: 1 microgram per kilogram body weight, placebo (normal saline serum) will be given during first 10 minutes after anesthesia and infusion will be administered in dosage of 0.9 microgram per kilogram body weight during per hour.
public Dr. Hamzeh Hosseinzadeh
Imam Reza Hospital, Golgasht Street
Tabriz Iran (Islamic Republic of) +98 41 3334 1994 hosseinz@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Dr. Hamzeh Hosseinzadeh
Imam Reza hospital, Golgasht Street
Tabriz Iran (Islamic Republic of) +98 41 3334 1994 hosseinz@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Class I or III according to ASA classification; aged between 18 to 65 year-old; candidate for elective thoracotomy with DLV. Exclusion criteria: severe cardiac disease; severe hepatic disease; severe renal disease; body mass index greater than 30; anemia (hemoglobin less than 12mg / dl ); chest trauma; sensitivity to dexmetedomidin 18 years 65 years Both J95 Intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified Treatment - Drugs Placebo control group: 1 microgram per kilogram body weight, dexmetedomidine will be given during first 10 minutes after anesthesia and infusion will be administered in dosage of 0.9 microgram per kilogram body weight during per hour. control group: 1 microgram per kilogram body weight, placebo (normal saline serum) will be given during first 10 minutes after anesthesia and infusion will be administered in dosage of 0.9 microgram per kilogram body weight during per hour. Evaluating dexmetedomidine effects on arterial oxygenation. Timepoint: 10 minutes after anesthesia and 20 minutes before end of the operation. Method of measurement: arterial blood oxygen saturation measurement. Measurement the use of other anesthetic agents during dexmetedomidine administration. Timepoint: during operation. Method of measurement: measuring dosage of anesthetic agents administered other than dexmetedomidine. Tabriz Medical University Approved 2016-07-17 Ethics committee of Tabriz University of Medical Sciences Vice chancellor for research, Tabriz university of medical sceinces, Daneshgah square Tabriz Iran (Islamic Republic of)