IRCT20170703034879N2 IRCT 2020-09-15 Tehran University of Medical Sciences Effect of rTMS on HSP Effect of repetitive trans-cranial magnetic stimulation (rTMS) of lower limb motor cortex on Lower extremity spasticity in patients with hereditary spastic paraplegia (HSP): A randomized sham-controlled double-blind study 2017-06-22 anticipated 10 Complete https://irct.ir/trial/50562 observational Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: We used computer-generated blocks for randomization. We asked a third party with no role in patient registration or data analysis to generate a number of blocks with 4 spots, 2 for intervention and 2 for sham. When the patient registration started, the person in charge of randomization was asked to start choosing a random block and inform the operator (who was an independent person with no role in patient registration and analysis) of the type of intervention for each patient in order of registration. in total 2 blocks of 4 were used for our 8 patients, Blinding description: For patient's in sham group, we used the same coil in active group but we placed it perpendicular to patient's scalp, therefore we were able to reproduce the somatic vibration sensation and acoustic artifact without stimulating motor cortex. As patients would receive intervention in separate appointments and there was no contact between patients, apart from the operator of rTMS, everyone -including the clinician who evaluated the outcomes and the analyst- was blind to the intervention for each patients. 3 Hereditary spastic paraplegia. Intervention 1: Intervention group: 5 sessions of 5 Hz rTMS on 5 consecutive days. each session comprised of 5 trains of 60 second duration and 2 minute inter train interval. Intervention 2: Control group: 5 sessions of sham rTMS with same duration as active intervention group with coil placed perpendicular to patient's scalp. Yes - There is a plan to make this available What will be shared: Mentioned information will be made available along with the manuscript as supplementary files. When: Same time as the publication of the manuscript To whom: All those who have access to the published manuscript. Conditions: Those who wish to perform further analysis on the data must submit their written request to the corresponding author of the article. Where to obtain: Corresponding author of the published manuscript. How to obtain: any request received by corresponding author will be shared with the research team and decision upon the requested permission will be made available to the applicant. Comments: