]>
IRCT20090701002114N6 IRCT 2020-09-21 Khoram-Abad University of Medical Sciences the effect of hydralazine and nifedipine on hypertension Comparative study of the effect of hydralazine and nifedipine on acute hypertension in women with preeclampsia 2020-09-12 anticipated 60 Complete https://irct.ir/trial/50651 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be assigned to the study groups in a simple, even and odd manner. The randomization tool will be the use of a random number table in such a way that people in the group of even numbers are characteristic of group one, ie hydralazine, and people with odd numbers in the group. 2 nifedipine will be placed, Blinding description: In the group receiving nifedipine, four doses of the drug will be given to the patient according to the instructions and intravenous injection of distilled water will be used to blind the patient. In contrast, in the group receiving hydralazine, the main drug will be injected intravenously at a dose of 5 mg. People in this group will use the placebo in pill form. N/A preeclampsia. Intervention 1: Intervention group: In intervention group number one, which includes receiving hydralazine. 5 mg of this drug will be slowly injected intravenously and to blind the samples in this group, an oral drug that has no drug content will be used. Blood pressure is checked every 20 minutes, and if there is a blood pressure of 160 over 110 mm Hg and more, another dose of the drug is injected. Intervention 2: Intervention group: Intervention group number two includes receiving nifedipine, which will be used as a 10 mg tablet. Intravenous distilled water will be used to blind the samples in this group. Blood pressure is checked every 20 minutes and if there is a blood pressure of 160 over 110 mm Hg and more, another dose of the drug is prescribed. Yes - There is a plan to make this available What will be shared: It is possible to share all the data while maintaining the principle of not mentioning the names of individuals When: One year after the publication of the related article To whom: Researchers of university centers Conditions: The data of the present study can be used after obtaining permission and approval from the Vice Chancellor for Research and Technology of Lorestan University of Medical Sciences Where to obtain: Refer to the project manager, Dr. Fatemeh Yari, with email address yari1672@yahoo.com, and contact number 09163613621 How to obtain: After completing the research and publishing the relevant article, individuals can apply to the Vice Chancellor for Research and Technology of Lorestan University of Medical Sciences to receive documents and after obtaining permission from this department, send a confirmation from the Vice Chancellor for Research to the project manager. Can access documentation. Comments:
public Fatemeh Yari
Medical school.,4 km Khorramabad Boroujerd Road.,Kamalvand
Khorramabad Iran (Islamic Republic of) 381351698 +98 66 3312 0133 yari.f@lums.ac.ir Khoram-Abad University of Medical Sciences scientific Fatemeh Yari
Medical school.,4 km Khorramabad Boroujerd Road.,Kamalvand
Khorramabad Iran (Islamic Republic of) 381351698 +98 66 3312 0133 yari.f@lums.ac.ir Khoram-Abad University of Medical Sciences Iran (Islamic Republic of) Pregnant women 18 to 45 years old Gestational age greater than or equal to 20 weeks Blood pressure greater than or equal to 160 over 110 18 years 45 years Female Maternal disease of any kind, including heart (heart arrhythmia - heart failure - chest pain, etc.), kidney, liver Fetal disorders including intrauterine growth restriction (IUGR) and Oligohydramnios Uncertain patterns of fetal heart rate o14 Treatment - Drugs Treatment - Drugs Intervention group: In intervention group number one, which includes receiving hydralazine. 5 mg of this drug will be slowly injected intravenously and to blind the samples in this group, an oral drug that has no drug content will be used. Blood pressure is checked every 20 minutes, and if there is a blood pressure of 160 over 110 mm Hg and more, another dose of the drug is injected. Intervention group: Intervention group number two includes receiving nifedipine, which will be used as a 10 mg tablet. Intravenous distilled water will be used to blind the samples in this group. Blood pressure is checked every 20 minutes and if there is a blood pressure of 160 over 110 mm Hg and more, another dose of the drug is prescribed. Systolic blood pressure. Timepoint: At the beginning of the study, then every twenty minutes until the blood pressure drops. Method of measurement: Using electronic blood pressure monitoring device. Diastolic blood pressure. Timepoint: At the beginning of the study, then every twenty minutes until the blood pressure drops. Method of measurement: Using electronic blood pressure monitoring device. Average blood pressure. Timepoint: At the beginning of the study, then every twenty minutes until the blood pressure drops. Method of measurement: Using electronic blood pressure monitoring device. Time to achieve controlled blood pressure. Timepoint: At the beginning of the study, then every twenty minutes. Method of measurement: Used in hours and in minutes. Khoram-Abad University of Medical Sciences Approved 2020-08-05 Ethics committee of Lorestan University of Medical Sciences Office of Research Ethics Committee, Vice Chancellor for Research and Technology of Lorestan University of Medical Sciences, University Campus Complex, km 3 of Khorramabad Boroujerd Road, Khorramabad Khorramabad Lorestan Iran (Islamic Republic of)