IRCT20190701044062N10 IRCT 2022-02-19 Tabriz University of Medical Sciences Effects of ANSIL in the treatment of anal fissures comparing the effect of the Ansil gel with placebo on the treatment of acute Anal fissure 2021-04-18 anticipated 50 Complete https://irct.ir/trial/50702 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be done in a simple way and using Graphpad software. Each group will be given the numbers A and B and The software will then generate random codes and based on those codes, patients will be provided with the desired drugs, Blinding description: A gel that has an active ingredient in silver nitrate with a gel that does not have a substance and is used as a placebo is completely identical in terms of the shape and size of the container, and the gels themselves do not differ in terms of odor and color, and are completely indistinguishable. The important point is that the patient is told that the gel used for the patient may be medication or medication. 2 acute Anal fissure. Intervention 1: Intervention group:0/2% َAnsil gel (Silver Nitrate) which is made using the nanoparticle mechanism at Tabriz University of Iran and is applied to the wound for two weeks, twice a day in the size of a fingertip. The patient is taught for 15 to 30 minutes by an experienced and trained expert. Intervention 2: Control group: These are the group that take placebo Gel that has no therapeutic properties. It is worth mentioning that the participants in this project are patients with acute anal fissure that placebo was used for this group. We remind you that according to the inclusion criteria, patients should not have used any topical anal drug for at least the last 7 days. Yes - There is a plan to make this available What will be shared: Part of the data, which includes information about the main outcome and results, will be shared. When: 5 months after printing the results To whom: Researchers working in academic institutions Conditions: The data will be available to researchers and university professors for the studies of the meta - analysis Where to obtain: Email: mh.hejazad@gmail.com How to obtain: Request via email: mh.hejazad@gmail.com As soon as possible Comments: