]>
IRCT20141209020258N148 IRCT 2020-09-21 Arak University of Medical Sciences Comparison of Dexmedetomidine Versus Ketamine-Propofol ‎combination versus Propofol for Sedation in Cataract Surgery Comparison of Dexmedetomidine Versus Ketamine-Propofol ‎combination versus Propofol for Sedation in Cataract Surgery 2020-06-30 anticipated 96 Complete https://irct.ir/trial/50945 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple individual randomization with random allocation with envelopes in 2 groups A and B and C. In this method, we selected a number of cards or letters as an intervention group and the same ‎number of cards for the control group, then the cards were merged. One card was taken out and its ‎allocation was registered and the card was returned to the other cards after leaving. Then the cards ‎are merged again and we remove another card. This process continues to reach a random sequence ‎according to sample size, Blinding description: This study is clinical trial.Outcome elevator and analyzer and participant are blind (double blind).Outcome elevator and analyzer and participant don't aware from grouping. 2-3 Cataract. Intervention 1: Intervention group 1: Dexmedetomidine dose of 0.5 microgram in kilogram will injected intravenously to patients in 10 minutes. Intervention 2: Intervention group: 20 milliliter of propofol and 2 milliliter of ketamine and 28 milliliter of normal saline are mixed. The resulting solution contains 4 milligram of propofol and 2 milligramof ketamine. 0.125 milliliter in kilogram in ten minutes. Intervention 3: Intervention group 3: They receive 0.3 milligram in kilogram of propofol by intravenous bolus injection and then 0.5 milligram in kilogram per hour by slow intravenous infusion. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Dr Alireza Kamali
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 68 3222 2003 alikamaliir@yahoo.com Arak University of Medical Sciences scientific Dr Mohammad Tavakolirad
Amiralmomenin hospital, Basij squre, Sardasht, Arak
Arak Iran (Islamic Republic of) 3814957558 +98 634173638 tavakoli@arakmu.ac.ir Arak University of Medical Sciences Iran (Islamic Republic of) Age 18 to 85 years Both sexes Candidate for cataract surgery Absence of mental disorders Lack of chronic history of sedatives No alcohol and drugs Lack of allergy to the drugs used Absence of severe obstructive pulmonary disease and name No history of heart disease, heart block and bradycardia Absence of systolic blood pressure less than 90 mm Hg Absence of severe liver failure Absence of uncontrolled diabetes Absence of cerebrovascular diseases 18 years 85 years Both Patient dissatisfaction Existence of any complication during sedation that leads to change of anesthesia schedule or cancellation of surgery. H25 Age-related cataract Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: Dexmedetomidine dose of 0.5 microgram in kilogram will injected intravenously to patients in 10 minutes. Intervention group: 20 milliliter of propofol and 2 milliliter of ketamine and 28 milliliter of normal saline are mixed. The resulting solution contains 4 milligram of propofol and 2 milligramof ketamine. 0.125 milliliter in kilogram in ten minutes Intervention group 3: They receive 0.3 milligram in kilogram of propofol by intravenous bolus injection and then 0.5 milligram in kilogram per hour by slow intravenous infusion. Pain. Timepoint: Every 5 minutes in surgery and recovery. Method of measurement: Visual analog scale pain. Arak University of Medical Sciences Approved 2020-06-28 Ethics comittee of Arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)