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IRCT20170413033408N4 IRCT 2020-10-14 Gorgan University of Medical Sciences effect of clonidine and magnesium sulfate on rhinoplasty Comparative study of clonidine and magnesium sulfate on bleeding control in septorhinoplasty surgery 2020-08-22 anticipated 86 Complete https://irct.ir/trial/51000 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: After selecting the participants who have the inclusion criteria to the study، How to allocate patients to one of the two drug groups will be done based on block randomization method. So that a random sequence of letters A and B is created by 43 double blocks and It will be provided to one of the members of the research team، This member will not interfere in the selection of samples, Blinding description: Participants are BLIND to their study group after obtaining their consent. The principal investigator will also not know the type of group therapy. All anesthesia procedures will be performed by an anesthesiologist who is unaware of the treatment groups under the same conditions and medication regimen for the participants, and information will be collected by an anesthesiologist unaware of the treatment groups. 3 Candidates for septorhinoplasty surgery. Intervention 1: first Intervention group: The clonidine is given to the patient by the head nurse one hour before the start of surgery in the ward. Intervention 2: second Intervention group: 50 mg/kg sulfate magnesium In normal saline it reaches a volume of 50 cc. Yes - There is a plan to make this available What will be shared: Information on the main outcome When: Since 2020 To whom: Researchers working in academic institutions Conditions: No manipulation, mentioning the data reference Where to obtain: Seyed Babak Mojaver Aghili, drbabaka35@gmail.com, Gorgan, 4 km, Sari, Golestan University of Medical Sciences, Gorgan, Iran. Deputy of Research and Technology, Gorgan, Golestan, Iran. How to obtain: sending an email, complete the personal and professional characteristics with documentation Comments:
public Seyed Babak Mojaver Aghili
Gorgan, 4 km, Sari, Golestan University of Medical Sciences, Gorgan, Iran. Deputy of Research and Technology of Gorgan, Golestan, Iran
Gorgan Iran (Islamic Republic of) 49341-74515 +98 17 3253 8011 drbabaka35@gmail.com Gorgan University of Medical Sciences scientific Seyed Babak Mojaver Aghili
Gorgan, 4 km, Sari, Golestan University of Medical Sciences, Gorgan, Iran. Deputy of Research and Technology of Gorgan, Golestan, Iran
Gorgan Iran (Islamic Republic of) 49341-74515 +98 17 3253 8011 drbabaka35@gmail.com Gorgan University of Medical Sciences Iran (Islamic Republic of) All patients with ASA I are candidates for septorhinoplasty 15 years 45 years Both Patients with known neuromuscular disease History of neuropathy Obese patients BMI> 35 History of coagulation disorders Renewed rhinoplasty History of calcium channel blockers A history of drug use NSAID, antiepileptic, TCA History of underlying diseases such as asthma, migraine History of allergies to drugs used for induction and anesthesia management used in these patients Z41.1 Other plastic surgery for unacceptable cosmetic appearance Treatment - Drugs Treatment - Drugs first Intervention group: The clonidine is given to the patient by the head nurse one hour before the start of surgery in the ward. second Intervention group: 50 mg/kg sulfate magnesium In normal saline it reaches a volume of 50 cc. The amount of bleeding volume. Timepoint: The measure of bleeding volume will be calculated from the beginning of the surgery until the end of the surgery. Method of measurement: patient bleeding is noted by collecting the blood in the bottle of suction, which is calibrated every 10 cc, and the calculation blood volume of gas in the patient’s throat. Hemodynamic changes. Timepoint: The patient's hemodynamic monitoring will be performed from the time of entering the operating room until the end of the operation. Method of measurement: Hemodynamic criteria (heart rate, systolic, diastolic, and mean arterial blood pressure (MABP), arterial oxygen saturation) of the patient will be measured by Saadat monitoring. Gorgan University of Medical Sciences Approved 2020-02-23 Ethics Committee of Golestan University of Medical Sciences Gorgan, 4 km, Sari, Golestan University of Medical Sciences, Gorgan, Iran. Deputy of Research and Technology of Gorgan, Golestan, Iran Gorgan Golestan Iran (Islamic Republic of)