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IRCT20181229042169N1 IRCT 2020-12-07 Shahroud University of Medical Sciences Comparison of intravenous remifentanil and intravenous lidocaine in prevention of cardiovascular response to laryngeal mask airway insertionl following anesthesia in limbs surgery. Comparison of remifentanil and lidocaine on controlling the cardiovascular response to laryngeal mask airway insertion following general anesthesia 2020-08-22 anticipated 60 Complete https://irct.ir/trial/51077 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple blind randomization Sixty identical sheets( 30 control and 30 intervention) were mixed in a bag and randomly one sheet brings out and the patients assigns to one group according this sheet and then the sheet is left out, Blinding description: Anesthesiologist and nurse anesthesia are aware of patient's group and this group is recorded in questionnaire by them. Questionnaire has two portion with identical cod. Nurse anesthesia separates data recording portion and gives it to person who is responsible of outcome recording and is unaware of patient grouping. syringes of remifentanil and lidocaine will be ready in identical shape and volume. 3 Open reduction and internal fixation of ulna and radiusfracture. Intervention 1: Intervention group: participants in intervention group after induction of anesthesia receives intravenous Remifentanil with a dose of 1.5 microgram/kg, and after 2 minutes ventilation Laryngeal Mask Airway will be inserted. Intervention 2: Control group: participants in control group after induction of anesthesia receives intravenous Lidocaine with a dose of 1.5 mg/kg, and after 2 minutes ventilation Laryngeal Mask Airway will be inserted. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available
public Dr Javad Nourian
Shahroud Haft Tir Square Shahroud University of Medical Sciences
Shahroud Iran (Islamic Republic of) 36147-73947 +98 23 3239 5054 javadnourian@gmail.com Shahroud University of Medical Sciences scientific Dr Javad Nourian
Shahroud Haft Tir Square Shahroud University of Medical Sciences
Shahroud Iran (Islamic Republic of) 36147-73947 +98 23 3239 5054 Mtkzf.ms@gmail.com Shahroud University of Medical Sciences Iran (Islamic Republic of) Male or female 18 - 60 years old Open limbs surgery under general anesthesia Class 1 and 2 of anesthesia risk (According to American society of anesthesiologist's classification) 18 years 60 years Both Difficult LMA placements Repeated attempts at LMA insertion Prolonged ( more than 30 seconds) LMA insertion S52.4 Fracture of shaft of radius Treatment - Drugs Treatment - Drugs Intervention group: participants in intervention group after induction of anesthesia receives intravenous Remifentanil with a dose of 1.5 microgram/kg, and after 2 minutes ventilation Laryngeal Mask Airway will be inserted. Control group: participants in control group after induction of anesthesia receives intravenous Lidocaine with a dose of 1.5 mg/kg, and after 2 minutes ventilation Laryngeal Mask Airway will be inserted. Systolic Blood pressure. Timepoint: Before induction of anesthesia - after induction of anesthesia - and immediately after laryngeal mask airway insertion. Method of measurement: Non-invasive blood pressure measurement with Novin Saadat monitor. Diastolic blood pressure. Timepoint: Before induction of anesthesia - after induction of anesthesia - and immediately after laryngeal mask airway insertion. Method of measurement: Non-invasive blood pressure measurement with Novin Saadat monitor. Pulse rate. Timepoint: Before induction of anesthesia - after induction of anesthesia - and immediately after laryngeal mask airway insertion. Method of measurement: Non-invasive blood pressure measurement with Novin Saadat monitor. Shahroud University of Medical Sciences Approved 2017-03-06 Ethics committee of Shahroud university of medical sciences Shahroud university of medical sciences , 7tir sq shahroud Semnan Iran (Islamic Republic of)