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IRCT20200928048867N1 IRCT 2020-10-22 Mashhad University of Medical Sciences Evaluation of short term outcomes of liver transplantation from COVID-19 positive deceased donors Evaluation of short term outcomes of liver transplantation from COVID-19 positive deceased donors 2020-10-01 anticipated 10 Complete https://irct.ir/trial/51319 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Acute liver failure. Intervention group: Patients with acute liver failure requiring urgent liver transplant. Yes - There is a plan to make this available What will be shared: IPD collected for the primary outcome measures are to be shared. When: starting 6 months after publication To whom: It's only available for people working in academic institutions Conditions: Requests for sharing data should be sent to the person responsible for general inquiries. Where to obtain: Requests for sharing data should be sent to the person responsible for general inquiries. Sara Saeidi Shahri saeidis971@mums.ac.ir 00989156846143 How to obtain: Requests should be accepted by scientific and executive team of study, then the data will be shared. Comments:
public Sara Saeidi Shahri
Ibne sina 21, NO.7
Mashhad Iran (Islamic Republic of) 009851 +98 51 3845 8671 saeidis971@mums.ac.ir Mashhad University of Medical Sciences scientific Mohsen Aliakbarian
General Surgery Department, Imam Reza Hospital, Ibnesina St.
Mashhad Iran (Islamic Republic of) 009851 +98 51 3852 5255 aliakbarianm@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Recipients with acute liver failue and MELD score> 20 requiring urgent liver transplant Recipients should have Negetive PCR test/ NO COVID-19 signs and symptoms/ NO lung involvement in HRCT Deceased donors with positive PCR tests or COVID-19 lung involvement in HRCT no limit no limit Both Recipients with clinical presentation of COVID-19 OR positive PCR test OR lung involvement in HRCT Deceased donors due to respiratory failure K74 Fibrosis and cirrhosis of liver Treatment - Surgery Intervention group: Patients with acute liver failure requiring urgent liver transplant Description of early outcomes of liver transplant from COVID-19 positive deceased donors. Timepoint: 30 days within operation. Method of measurement: Clinical assessments/ liver functional tests. Evaluation of transmission of COVID-19. Timepoint: 24 hours, day 7 and 14 postoperatively. Method of measurement: Clinical manifestations, PCR test, lung HRCT. Long term outcomes of liver transplant from COVID-19 positive deceased donors. Timepoint: 6 months and 1 year postoperatively. Method of measurement: Clinical follow ups and liver function tests. Mashhad University of Medical Sciences Approved 2020-09-26 Ethics committee of Mashhad University of Medical Sciences General Surgery Department, Imam Reza Hospital, Ibnesina St. Mashhad Razavi Khorasan Iran (Islamic Republic of)