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IRCT201305204811N3 IRCT 2015-05-23 Vice chancellor for research, Iran University of Medical Sciences Determining intestinal metaplasia and dysplasia in obese patients candidate for surgery Gastric mapping for intestinal metaplasia and dysplasia in morbid obese patients candidate for bariatric surgery 2015-06-22 anticipated 174 Complete https://irct.ir/trial/5163 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Diagnostic. 0 (exploratory trials) Condition 1: Obesity and sleep apnea. Condition 2: Obesity. Condition 3: all types of obesity. Condition 4: Morbid obesity. All patients who sign an informed consent form will be endoscopically evaluated and gastric biopsy will be done. CBC, platelet, ESR, CRP, FBS, TG, Chol, HDL, and LDL will also be determined after taking blood sample. Endoscopy will be done before surgery under sedation with propofol and after confirming by a cardiologist..
public Ali Kabir
Minimally invasive surgery research center and Endoscopy ward of the Hazrat Rasoul-e- Akram Hospital, Mansouri St., Sattarkhan Ave.
Tehran Iran (Islamic Republic of) 00 aikabir@yahoo.com Iran University of Medical Sciences scientific Ali Kabir
Minimally invasive surgery research center and Endoscopy ward of the Hazrat Rasoul-e- Akram Hospital , Mansouri St., Sattarkhan Ave.
Tehran Iran (Islamic Republic of) +98 21 6655 5448 aikabir@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Morbid obese patients (BMI > 35 kg/m2), aged between 18 and 70 years old who are not involved in any other interventional study, have tendency for doing upper endoscopy and gastric biopsy. Exclusion criteria: Cases with any severe diseases of kidney and heart and any other end stage diseases. 18 years 70 years Both E66.2 E66.0 E66.9 E66.8 Extreme obesity with alveolar hypoventilation Obesity due to excess calories Simple obesity NOS Morbid obesity Diagnosis All patients who sign an informed consent form will be endoscopically evaluated and gastric biopsy will be done. CBC, platelet, ESR, CRP, FBS, TG, Chol, HDL, and LDL will also be determined after taking blood sample. Endoscopy will be done before surgery under sedation with propofol and after confirming by a cardiologist. Gastric dysplasia. Timepoint: At the beginning of study. Method of measurement: gastric biopsy. Mucosal atrophy. Timepoint: At the beginning of study. Method of measurement: gastric biopsy. H. pylori infection. Timepoint: At the beginning of study. Method of measurement: gastric biopsy. Gastric metaplasia. Timepoint: At the beginning of study. Method of measurement: gastric biopsy. Chronic gastritis. Timepoint: At the beginning of study. Method of measurement: gastric biopsy. Reactive atypia of glandular epithelium. Timepoint: At the beginning of study. Method of measurement: gastric biopsy. FBS. Timepoint: at the beginning of study. Method of measurement: ELISA. TG. Timepoint: at the beginning of study. Method of measurement: ELISA. Total Cholestrol, LDL, HDL. Timepoint: at the beginning of study. Method of measurement: ELISA. CRP, ESR. Timepoint: at the beginning of study. Method of measurement: ELISA. Vice chancellor for research, Iran University of Medical Sciences Approved 2015-05-11 Ethics committee of Iran University of Medical Sciences 5th Floor, Central Building of Iran University of Medical Sciences,Hemmat Expway, between Sheikh fazlollah and Chamran Expway Tehran Iran (Islamic Republic of)