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IRCT20201017049052N1 IRCT 2020-11-23 Ahvaz University of Medical Sciences Effect of magnesium sulfate and nifedipine in preterm labor Comparison of magnesium sulfate and nifedipine in treatment of preterm labor in pregnant women with 28-34 weeks of gestational age. 2019-06-01 anticipated 100 Complete https://irct.ir/trial/51685 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Restricted randomisation of the random allocation role type, This method represents a large block for the entire sample size, This means that a balance in the number of people assigned to each group will be achieved at the end of the study. For this purpose, it first determines a total sample size and then randomly assigns a set of them to group A and the remainder to group B.This method is used for two or more group trials, Blinding description: For blindness, the nifedipine group received Ringer serum in addition to oral medication and the magnesium sulfate group received oral placebo in addition to the injectable drug, and thus the patient, physician, and treatment staff of the patients under study have no knowledge of allocation of individuals to the groups. 2 Preterm Labor. Intervention 1: Intervention group 1: Nifidipine recipient with an initial dose of 20 mg orally and then every 6 hours for 24 hours. Intervention 2: Intervention group 2: Recipient of 20% magnesium sulfate with an initial dose of 4 gram intravenously and then 2 gram per hour for 24 hours. Yes - There is a plan to make this available What will be shared: All data of study participants can be shared after making people and the entire study protocol unidentifiable. When: After publishing the results under the title of dissertation and also after registering in the Behsan system of Ahvaz Jundishapur University of Medical Sciences To whom: Researchers working in academic and scientific institutions Conditions: The use of all study materials without mentioning the source is unrestricted. Where to obtain: Central Library of Ahvaz Jundishapur University of Medical Sciences WWW.centrallib.ajums.ac.ir How to obtain: Access to the dissertation section is easily possible through the Central Library website. Comments:
public Mina Mahdavi
Unit 10,Tara Building, No 75, Second Phase, 2nd West St., Kianpars
Ahvaz Iran (Islamic Republic of) 61558-19619 +98 61 3337 6318 mina.m349@yahoo.com Ahvaz University of Medical Sciences scientific Nahid Shahbazian
Imam Khomeini Hospital; Azadegan street
Ahvaz Iran (Islamic Republic of) 61936-73111 +98 61 3222 2922 nahid.shahbazian@yahoo.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) Single fetus pregnancy Pregnancy in 28_34 weeks of gestational age Not in the active phase of labor No contraindication to continue pregnancy no limit no limit Female Any situation that makes it impossible to continue the pregnancy Contraindications to the use of Nifedipin or Magnesium sulfate in the patient O60.00 Preterm labor without delivery, unspecified trimester Treatment - Drugs Treatment - Drugs Intervention group 1: Nifidipine recipient with an initial dose of 20 mg orally and then every 6 hours for 24 hours Intervention group 2: Recipient of 20% magnesium sulfate with an initial dose of 4 gram intravenously and then 2 gram per hour for 24 hours Delaying preterm delivery for more than 48 hours. Timepoint: Measurement of dilatation and effaceman of the cervix before treatment and 24 hours and 48 hours after treatment. Method of measurement: Manual vaginal examination. Drug side effects. Timepoint: Frequently after starting treatment until the end of the dose. Method of measurement: Patient statement and questionnaire. Ahvaz University of Medical Sciences Approved 2019-05-31 Ethics committee of Ahvaz Jundishapur University of Medical Sciences Unit 10, Tara Building, No 75, Second Phase, 2nd West St., Kianpars Ahvaz Khouzestan Iran (Islamic Republic of)