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IRCT20200823048491N1 IRCT 2020-12-20 Esfahan University of Medical Sciences The effect of N-acetylcysteine ​​(NAC) on renal failure in Coronary surgery Evaluation of the effect of N-acetylcysteine ​​(NAC) in cardio-pulmonary pump device in preventing kidney failure in coronary heart surgery 2020-02-24 anticipated 100 Complete https://irct.ir/trial/51787 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Patients undergoing open heart surgery. Intervention 1: Intervention group for patients taking 1200 mg of NAC once in prime during cardiopulmonary pumping 1200 mg of NAC. Intervention 2: Control group: For patients who are not taking NAC. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Leila Roustazadeh Sheikh Yousefi
Isfahan, third Mushtaq street, Zayandehrud town
Esfahan Iran (Islamic Republic of) 8158345932 +98 31 3532 0882 LEILAEOSTA3131@GMAIL.COM Esfahan University of Medical Sciences scientific Leila Roustazadeh Sheikh Yousefi
Isfahan, third Mushtaq street, Zayandehrud town
Esfahan Iran (Islamic Republic of) 8158345932 +98 31 3532 0882 leilaeosta3131@gmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Age 40 to 65 years GFR greater than 60 Creatinine less than 1.5 Having conscious satisfaction Patients with no previous history of open heart surgery Patients undergoing CABG coronary artery bypass graft surgery Patients who did not use ECMO and pump balloons before open heart surgery 40 years 65 years Both Patients undergoing CABG without Cardiopulmonary pump (CPB) Patients who had valve surgery in addition to CABG surgery Patients who are candidates for emergency CABG Treatment - Drugs Treatment - Other Intervention group for patients taking 1200 mg of NAC once in prime during cardiopulmonary pumping 1200 mg of NAC Control group: For patients who are not taking NAC Evaluation of BUN. Timepoint: One and two days after surgery. Method of measurement: Through blood tests and sheets available in the ICU. Creatinine. Timepoint: One and two days after surgery. Method of measurement: Through blood tests and sheets available in the ICU. Urinary output. Timepoint: One and two days after surgery. Method of measurement: Through blood tests and sheets available in the ICU. Esfahan University of Medical Sciences Approved 2020-02-24 Ethics Committee of Isfahan University of Medical Sciences Isfahan, Hezar Jerib St, Isfahan University of Medical Sciences Esfahan Isfehan Iran (Islamic Republic of)