IRCT20201022049108N1 IRCT 2020-11-05 Karaj University of Medical Sciences Evaluation of the effects of prophylactic misoprostol with oxytocin for postpartum hemorrhage in women with preeclampsia Evaluation of the Efficacy of Rectal or Sub-linguinal Misoprostol concomitant with Oxytocin for Prevention of Postpartum Hemorrhage in women with preeclampsia 2020-11-21 anticipated 128 Complete https://irct.ir/trial/51799 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Pocket shuffling, In this study for a total sample size of 128, the principle investigator write number 1 on 43 blanck cards, number 2 on 43 blanck cards, number 3 on 43 blanck cards. Then, she place them in non-transparent pockets, then give all of them to another person that will shuffle them and put them in a box and give the box back to PI. For every patients included in the study, the PI picks up one card and assign the patient to one of the 3 groups based on the information on that card. The rest of the cards is then shuffled again and placed in a box to be used by another patient. This continues until the last patient, Blinding description: First, dark envelopes were prepared for the number of total sample size, the inside of which was not visible in the light, and a paper that the name of groups was written on them were placed in them and placed in the operating room. The surgeon picks up an envelope and gives it to the PI. Based on the information in the envelope, the PI prescribes the medication for the patient. The patients and data analyzer will not know what kind of tratment were prescribed. 3 severe pre-eclampsia. Intervention 1: Intervention group: Oral misoprostol manufactured in Aboorehyan pharmacy CO, Iran, give to patients sublingually after C-section it is in combination with conventional treatment that is infusion of 30 IU (3 X ampule 10 IU/mL) of same company. Intervention 2: Control group: Without Intervention: after C-section aconventional treatment that is infusion of 30 IU (3 X ampule 10 IU/mL) of Abooreyhan pharmacy CO. Iran. will give to patients. Intervention 3: Intervention group: rectal misoprostol, Oral misoprostol manufactured in Aboorehyan pharmacy CO, iran, give to patients rectally after C-section it is in combination with conventional treatment that is infusion of 30 IU (3 X ampule 10 IU/mL) of same company. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Patients unsatisfication for sharing their information