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IRCT20201014049022N1 IRCT 2020-11-15 Tehran University of Medical Sciences Improving oxidant effects following open heart surgery The effect of remote ischemic preconditioning (RIPC) on total antioxidant capacity (TAC) patients under coronary artery bypass grafting (CABG) 2020-10-22 anticipated 50 Complete https://irct.ir/trial/51907 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: The studied patients will be divided into two groups of intervention under RIPC and control. We use a simple randomization method for allocating patients into two groups. Each randomization unit is an individual that is assigned with a random number between zero and one using Excel software. Patients with a number greater than or equal to 0.5 are in the RIPC intervention group and the group with a number of less than 0.5 is in the control group. The anesthesiologist and the anesthesia nurse are aware of the group the patient is in and perform the intervention in the RIPC and control groups. The surgeon, the nurse recording the outcomes, and the laboratory expert who performs the laboratory tests have no knowledge of the study groups, Blinding description: The anesthesiologist and the anesthesia nurse are aware of the group the patient is in and perform the intervention in the RIPC and control groups. In the next stages, all interventions are similar in both groups, and the surgeon and the nurse recording the outcomes are not aware of the study group. Then, the samples drawn by the anesthesia team are coded confidentially. Therefore, the laboratory expert who performs the laboratory tests have no knowledge of the study groups. N/A Coronary artery bypass grafting. Intervention 1: Intervention group: inflation of the blood pressure cuff for 5 minutes and deflation for 5 minutes with 4 repeats. Intervention 2: Control group: no intervention. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.
public Farhad Gorjipour
Shahid Madani St.
Tehran Iran (Islamic Republic of) 1617763141 0098 21 73430 gorjipoorf@yahoo.com Shahid Beheshti University of Medical Sciences scientific Mohammad Javad Mehrbanian
North Karegar, Jalal-e-Al-e-Ahmad cross.
Tehran Iran (Islamic Republic of) 1313814117 +98 21 8802 9600 mehrabanian56@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Candidate for coronary artery bypass grafting with cardiopulmonary bypass Normal upper limb examinations Not having surgical operations in the past three months Not having acute medical conditions during the last three months no limit no limit Both Known inflammatory disorders Diabetes Liver disease Kidney disease Receiving vitamins C and/or E and/or other antioxidants Z95.1 Presence of aortocoronary bypass graft Treatment - Other Other Intervention group: inflation of the blood pressure cuff for 5 minutes and deflation for 5 minutes with 4 repeats Control group: no intervention Total antioxidant capacity. Timepoint: After anesthesia induction, after cardiopulmonary bypass, 24 hours after intensive care unit admission. Method of measurement: With turbidimetry analysis. Glutathione peroxidase activity assay. Timepoint: After anesthesia induction, after cardiopulmonary bypass, 24 hours after intensive care unit admission. Method of measurement: With turbidimetry analysis. Troponin level. Timepoint: After anesthesia induction, after cardiopulmonary bypass, 24 hours after intensive care unit admission. Method of measurement: ELISA. Ejection fraction. Timepoint: Every 8 hours after intensive care unit admission. Method of measurement: Echocardiography. Tehran University of Medical Sciences Approved 2020-07-28 Ethics committee of Tehran University of Medical Sciences Tehran University of Medical Sciences, Qods street cross., Keshavarz Blvd. Tehran Tehran Iran (Islamic Republic of)