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IRCT138707091282N1 IRCT 2011-04-12 Isfahan University of Medical Sciences and Health Services Evaluation of changes in urinary parameters after oral administration of magnesium chlorides and potassium citrate in pediatric with calcium oxalate urolithiasis. Evaluation of changes in urinary parameters after oral administration of magnesium chlorides and potassium citrate in pediatric with calcium oxalate urolithiasis. 2008-02-02 anticipated 40 Complete https://irct.ir/trial/520 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Used, Assignment: Single, Purpose: Prevention. N/A urolithiasis. Intervention 1: Phase 1: Oral solution of potassium citrate, 0.5 cc/kg/dose, every 8 hours, 30 min after meal, for 4 weeks. Intervention 2: Phase 2: Combination of K Citrate 0.5 cc/kg/dose, every 8 hours, 30 min after meal as well as Mg Chloride 10-20 mg/kg/dose equivalent to 180 meq elemental Mg for 4 weeks.
public Dr Alaleh Gheisary
Isfahan University of Medical Sciences, Hezarjarib St., Isfahan
Isfahan Iran (Islamic Republic of) +98 913 313 3563 gheisari@med.mui.ac.ir Isfahan University of Medical Sciences and Health Services scientific Dr Alaleh Gheisary
Isfahan University of Medical Sciences, Hezarjarib St., Isfahan
Isfahan Iran (Islamic Republic of) +98 913 313 3563 gheisari@med.mui.ac.ir Isfahan University of Medical Sciences and Health Services Iran (Islamic Republic of) Inclusion criteria: age 2-12 years with possibility of calcium oxalate kidney stone, No past history of peptic ulcer, chronic diarrhea or cardiac disease, primary hyperparathyroidism, consumption of anticonvulsants, No proven history of disorders affecting tubular ion excretion such as: recent urinary tract infection , distal renal tubular acidosis , chronic pyelonephritis, renal dysfunction and obstructive uropathy Exclusion criteria: Patients who did not complete all steps of the study, refusing to consume either potassium citrate or magnesium chloride 2 years 18 years Male N20 Calculus of kidney and ureter Treatment - Drugs Treatment - Drugs Phase 1: Oral solution of potassium citrate, 0.5 cc/kg/dose, every 8 hours, 30 min after meal, for 4 weeks Phase 2: Combination of K Citrate 0.5 cc/kg/dose, every 8 hours, 30 min after meal as well as Mg Chloride 10-20 mg/kg/dose equivalent to 180 meq elemental Mg for 4 weeks Urine parameter (Ca-K-Na-Cl-Cit-Ox-P-Cr-Mg). Timepoint: Before and4 weeks after intervention. Method of measurement: 24-hour urine test. Blood parameter (Ca-K-Na-Cl-Cit-Ox-P-Cr-Mg). Timepoint: Before and 4 weeks after intervention. Method of measurement: blood test. Isfahan University of Medical Sciences and Health Services Approved 2008-08-20 Isfahan University of Medical Sciences and Health Services Isfahan University of Medical Sciences, Hezarjarib St., Isfahan Isfahan Iran (Islamic Republic of)