IRCT20200803048281N1 IRCT 2020-11-29 Tehran University of Medical Sciences The effect of chemotherapy in rectal cancer The evaluation of pathologic complete response and clinical complete response in locally advanced rectal cancer who treated with total neoadjuvant therapy compared with standard treatment 2019-09-23 anticipated 70 Complete https://irct.ir/trial/52086 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are randomized to two groups by Permuted block method;The group treated with TNT approach and the group treated with standard treatment. Randomization method: block Randomization unit: individual Randomization tool: online software (Sealed Envelope Ltd. 2020) How to make a random sequence: Online software at: https://www.sealedenvelope.com/simple-randomiser/v1/lists [Accessed 6 Nov 2020]. 3 Rectal cancer. Intervention 1: Intervention group: The intervention group will include patients who have all chemotherapy sessions before surgery, 3 sessions before radiotherapy and 3 sessions after radiotherapy. Medications include oxaliplatin 135 mg / m2, d1, and capecitabine (ACTe) 1000 mg / m2, d1-d14 every three weeks. Concurrently with radiotherapy, capcitabine 825 mg / m2 is prescribed during the radiotherapy treatment. Intervention 2: Control group: The control group includes patients who are treated by the standard protocol; preoperative chemoradiation and postoperative chemotherapy. Capecitabin is prescribed at a dose of 825 mg /m2 during radiotherapy, and after surgery, chemotherapy includes oxaliplatin 135 mg / m2, d1 and capecitabin (Acte company) 1000 mg / m2, d1-d14 every three weeks up to 5-6 courses. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more information.