IRCT20201106049288N1 IRCT 2020-12-23 Tehran University of Medical Sciences Effect of probiotics mouthwash and normal saline in treatment of mucositis Comparision of the effect of probiotics mouthwash and normal saline in the treatment of radiotherapy induced mucositis 2021-01-20 anticipated 64 Complete https://irct.ir/trial/52102 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: A simple randomization method is used. For randomization, randomly selected pre-radiotherapy use is selected for inclusion in the study. The first step in performing a random process is to create a random sequence. The second step after creating a random sequence is sequencing generating technology (property privatization acquisition). The purpose of these steps is to prevent any predictions of future allocation by drug sales and distribution companies. Both groups compete with each other using age and gender, and the age of the people in the case group is controlled by the average age of the people in the control group, and thus matching between the two groups takes place, Blinding description: In addition to the patient, the person giving the mouthwash to the patient does not know the type of mouthwash. 2 Radiotherapy-induced oral mucositis. Intervention 1: Intervention group: Probiotic mouthwash is used to prepare probiotic mouthwash from Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus salivarius, Lactobacillus ruteri, Bifidobacterium lactobacillus, Bactidobacterium lactobacillus, The combination of bacteria is prepared in powder form and is provided to the therapist and the patient as a pre-prepared solution. Intervention 2: Intervention group: To prepare normal saline mouthwash from Tween 80 (500 mg), 5 (Avicel g) and xanthan (2 g), methyl paraben (8.1 g), propyl paraben (200 mg), disodium hydrogen phosphate (2 g), sodium dihydrogen phosphate (3 g) and distilled water are used. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No further information available at this time.