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IRCT20201110049345N1 IRCT 2020-12-01 Mashhad University of Medical Sciences Effect of Systemic Prednisolone and Topical Tranexamic Acid on Prevention of Rebleeding in Traumatic Hyphema Comparison of the Effect of Systemic Prednisolone and Topical Tranexamic Acid on Prevention of Rebleeding in Patients with Traumatic Hyphema 2018-08-23 anticipated 80 Complete https://irct.ir/trial/52222 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: In order to randomize, sequence production was performed using PASS software. Allocation concealment was also done through envelopes, Blinding description: Participants randomly divided in two groups by random table numbers and take medications.outcome assessors and data analysers don’t informed about goal of study. 2 Hyphema. Intervention 1: Patients with traumatic hyphema recived Topical Tranzamic Acid5% made by sterilization specialists of Mashhad University of Medical Sciences were administered every 6 hours for 5 days or until clot absorption (each occurred earlier). Intervention 2: Patients with traumatic hyphema who were given prednisolone tablets at a dose of 1 mg / kg for 5 days or until clot absorption (whichever occurs earlier). Yes - There is a plan to make this available What will be shared: All data of hyphema and rebleeding When: starting 6 months after publication To whom: All people Conditions: All academic peoples Where to obtain: E-mail: firoozij951 @mums.ac.ir How to obtain: As soon as possible Comments:
public Akbar Derakhshan
Khatam Al-Anbia Eye Hospital, Aboutaleb Intersection
Mashhad Iran (Islamic Republic of) 9195965919 +98 51 3728 9911 DerakhshanA@mums.ac.ir Mashhad University of Medical Sciences scientific Akbar Derakhshan
Khatam Al-Anbia Eye Hospital, Aboutaleb Intersection
Mashhad Iran (Islamic Republic of) 9195965919 +98 51 3728 9911 DerakhshanA@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Patients with Traumatic Hyphema referred to Mashhad Eye "Khatam AlAnbia Hospital" 7 years no limit Both Microscopic hyphema Globe rupture Patients with systemic diseases such as diabetes mellitus, hypertension Posterior segment pathology except commotio retina coagulopathy and taking anticoagulants drugs history of ophthalmic surgery children under 7years old pregnant women. H21.0 Hyphema Prevention Prevention Patients with traumatic hyphema recived Topical Tranzamic Acid5% made by sterilization specialists of Mashhad University of Medical Sciences were administered every 6 hours for 5 days or until clot absorption (each occurred earlier). Patients with traumatic hyphema who were given prednisolone tablets at a dose of 1 mg / kg for 5 days or until clot absorption (whichever occurs earlier). Rebleeding. Timepoint: Daily for 5 days and two weeks later. Method of measurement: Slit lamp biomicroscopy. Mashhad University of Medical Sciences Approved 2018-08-18 Ethics committee of Mashhad university of medical science. Knowledge and Health City of Mashhad university of medical science – In the end of Shahid Fakouri Blvd (In front of Fakouri 94) – Mashhad - Iran Mashhad Razavi Khorasan Iran (Islamic Republic of)