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IRCT20160202026328N6 IRCT 2020-11-22 Tabriz University of Medical Sciences Comparison of hemodynamic changes in hypertensive patients after dexmedetomidine and midazolam injection Comparison of hemodynamic response during anesthesia induction using Dexmedetomidine and Midazolam in hypertensive patients undergoing orthopedic surgery 2020-11-21 anticipated 130 Complete https://irct.ir/trial/52285 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Factorial, Purpose: Diagnostic, Randomization description: Through a randomly generated computer-generated list, individuals in 4-person blocks will be assigned to two intervention groups, Blinding description: In this research, the thesis owner student provides the drugs to the anesthesiologist and is the only person who is not blind to the study.The anesthesiologist, who is in charge of the patient's anesthesia management, injects the drug through coded syringes that have already been prepared by the thesis owner. So that anesthesiologist is unaware of the injected drug to patient during injection.The anesthesia nurse, who is responsible for collecting information and variables from the patient and is unaware of the type of prescribed drug, fills in the checklist during surgery and recovery.The patient is also unaware of the type of Injecting drug. 2 Comparison of hemodynamic changes in anesthetized patients with hypertension following dexmedetomidine and midazolam injection.. Intervention 1: Intervention group1: in the first intervention group, 10 μg / kg dexmedetomidine will be injected 5 minutes before anesthesia. Intervention 2: Intervention group 2: in the second intervention group, 0.03 mg / kg midazolam will be injected 5 minutes before anesthesia. Yes - There is a plan to make this available What will be shared: All potential data can be shared after making peoples unrecognizable. When: Starting 6 months after publication To whom: Documents will be available for people working in academic institutions and also people working in businesses. Conditions: There will be no specific limitations to the utilization of the data Where to obtain: Dr .Masoud Parish , Department of Anesthesiology, Faculty of Medicine, Golgasht Street, Tabriz East Azarbaijan Islamic Republic of Iran ,Phone+98 413 3341994, Fax+98 41 33341994 , masoudparish@yahoo.com How to obtain: Applicants will access the data from the present study by sending an email to the responsible author for a maximum of one week. Comments:
public Masoud Parish
Shohada Hospital, Golshahr Ave.
Tabriz Iran (Islamic Republic of) 5167846171 +98 41 3389 3517 masoudparish@yahoo.com Tabriz University of Medical Sciences scientific Masoud Parish
Shohada Hospital, Golshahr Ave.
Tabriz Iran (Islamic Republic of) 5167846171 +98 41 3389 3517 masoudparish@yahoo.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Patients 40 to 70 years old Known hypertensive treated patients Candidate for elective orthopedic surgery 40 years 70 years Both Patients treated with psychotic drugs Emergency patients Traumatic patients with heavy bleeding Liver and kidney disorders Patients with ischemic heart disease Patients with severe systemic vascular disease T88.59 Other complications of anesthesia Treatment - Drugs Treatment - Drugs Intervention group1: in the first intervention group, 10 μg / kg dexmedetomidine will be injected 5 minutes before anesthesia. Intervention group 2: in the second intervention group, 0.03 mg / kg midazolam will be injected 5 minutes before anesthesia. Systolic blood pressure. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Mercury barometer. Diastolic blood pressure. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Mercury barometer. Heart rate. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Counting in each minutes. Saturation of peripheral oxygen. Timepoint: 5 minutes before entering the operating room, the moment of entering, 5 minutes after lying down in a relaxed state, immediately after the injection of the intervention drug, 5 minutes after the injection and then every 15 minutes until the end of the operation. Method of measurement: Via the Pulse Oximeter. Tabriz University of Medical Sciences Approved 2020-08-10 Ethics committee of Tabriz University of Medical Sciences Faculity of Medicine, Golgasht Street Tabriz East Azarbaijan Iran (Islamic Republic of)