IRCT20140203016473N12 IRCT 2021-02-07 Tabriz University of Medical Sciences Effect of chemoradiotherapy on locally advanced cancer of Cardia Effect of Neoadjuvant Chemoradiotherapy on Downstaging of Locally Advanced Cancer of Cardia and patient's survival 2020-04-20 anticipated 60 Complete https://irct.ir/trial/52400 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment, Other design features: In this study, all patients with cardiac cancer diagnosis will be examined for the stage of tumor before and after receiving chemoradiotherapy , Blinding description: The outcome assessor who is responsible for assessing the stage of the disease before and after the intervention (using the results of radiological reports) will be blinded to whether the intervention was performed on patients (before or after the intervention). 2-3 Cardia cancer. Intervention group: Patients on FC diet containing 5-fluorouracil 800 mg / m2 intravenously (Alhavi Pharmaceutical Co.), continuous intravenous infusion for 24 hours daily on days 1 to 5 and cisplatin 15 mg / m2 intravenously (Sobhan Oncology Pharmaceutical Co.), daily injection on days 1 to 5 for two periods Every 21 days with 25 sessions of 45Gy radiotherapy for 2 minutes, high energy - 18 mV. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is confidential