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IRCT20201125049491N1 IRCT 2020-12-28 Tehran University of Medical Sciences The effect of daily consumption of probiotic yogurt on albumin to creatinine Ratio, eGFR and metabolic parameters in type 2 diabetic patients with microalbuminuria The effect of daily consumption of probiotic yogurt on albumin to creatinine Ratio, eGFR and metabolic parameters in type 2 diabetic patients with microalbuminuria 2021-11-11 anticipated 60 Complete https://irct.ir/trial/52623 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Each person is assigned a code and this code is entered into Excel software, and then used to randomize the rand function of Excel software, Blinding description: The shape, appearance, packaging, color and smell of both probiotic and non-probiotic yogurts will be quite similar. In addition, the person who provides yogurts to patients is aware of the type of yogurt, but the researcher and the patient are not aware of it. N/A Diabetic nephropathy. Intervention 1: Intervention group: They will receive 300g of probiotic yogurt(Haraz Company) enriched with Bifidobacterium lactis and Lactobacillus acidophilus strains daily for 8 weeks. Microbiological analyzes showed that the average colony content of both strains is 10 ^ 6 CFU / g. Intervention 2: Control group: Control group: 300g will receive normal yogurt from Haraz company for 8 weeks. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more information
public Seyed Mojtaba Ghoreishy
Faculty of Nutrition and Dietetics, No. 44, Hojjatdoost Alley, Naderi St., Keshavarz Boulevard
Tehran Iran (Islamic Republic of) 3913883361 +98 86 4222 8244 seyed.mojtaba.ghoreishy@gmail.com Tehran University of Medical Sciences scientific Seyed Mojtaba Ghoreishy
Faculty of Nutrition and Dietetics, No. 44, Hojjatdoost Alley, Naderi St., Keshavarz Boulevard
Tehran Iran (Islamic Republic of) 3913883361 +98 86 4222 8244 seyed.mojtaba.ghoreishy@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Diabetic nephropathy with microalbuminuria (Albumin to creatinine ratio 30-299 mg / g Cr, eGFR≥ 30 ml / min / 1.73m2) Has an age of 80-20 years BMI less than 40 kg / m2 20 years 80 years Both History of chronic diseases including: IBD, liver disease, rheumatoid arthritis, renal disorders except diabetic nephropathy Smoking, alcohol and tobacco History of taking antibiotics and NSAIDS (during the last month) Take omega 3 supplements and vitamins E and C during the last three months Consumption of probiotic supplements or foods containing probiotics during the last three months Lactose intolerance Pregnancy E11.21 Type 2 diabetes mellitus with diabetic nephropathy Rehabilitation Placebo Intervention group: They will receive 300g of probiotic yogurt(Haraz Company) enriched with Bifidobacterium lactis and Lactobacillus acidophilus strains daily for 8 weeks. Microbiological analyzes showed that the average colony content of both strains is 10 ^ 6 CFU / g. Control group: Control group: 300g will receive normal yogurt from Haraz company for 8 weeks Albumin to creatinine ratio. Timepoint: First the intervention and 8 weeks later at the end of the intervention. Method of measurement: Laboratory kits. EGFR. Timepoint: At the beginning of the intervention and 8 weeks later at the end of the intervention. Method of measurement: Special laboratory kit. TG. Timepoint: At the beginning of the intervention and 8 weeks later at the end of the intervention. Method of measurement: Special laboratory kit. TC. Timepoint: At the beginning of the intervention and 8 weeks later at the end of the intervention. Method of measurement: Special laboratory kit. LDL. Timepoint: At the beginning of the intervention and 8 weeks later at the end of the intervention. Method of measurement: Special laboratory kit. HDL. Timepoint: At the beginning of the intervention and 8 weeks later at the end of the intervention. Method of measurement: Special laboratory kit. FBS. Timepoint: At the beginning of the intervention and 8 weeks later at the end of the intervention. Method of measurement: Special laboratory kit. HbA1c. Timepoint: At the beginning of the intervention and 8 weeks later at the end of the intervention. Method of measurement: Special laboratory kit. Hs-CRP. Timepoint: At the beginning of the intervention and 8 weeks later at the end of the intervention. Method of measurement: Special laboratory kit. Diabetes Research Center, Research Institute of Endocrinology and Metabolism, Tehran University of Medical Sciences Approved 2020-09-19 Ethics Committee of Tehran University of Medical Sciences First Floor, Faculty of Medicine, Building No. 1, North Door of the University, POURSINA St, GHODS St, ENGHELAB St Tehran Tehran Iran (Islamic Republic of)