IRCT20150613022681N4 IRCT 2021-01-02 Esfahan University of Medical Sciences Evaluation of the effect of curcumin piperine supplementation in patients with sepsis admitted to the intensive care unit (ICU): a double-blind randomized controlled clinical trial The effect of curcumin piperine supplementation on inflammation, length of stay, and 28-day mortality in patients with sepsis admitted to the intensive care unit (ICU): a double-blind randomized controlled clinical trial 2021-01-20 anticipated 66 Complete https://irct.ir/trial/52661 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: Randomization will be conducted using the block randomization method (permuted blocked randomization). depending on the sample size, each block includes 4 characters and will be used AABB combination. In the following, all possible modes from the combination will be listed and a code will be allocated to each patient. This will be done using a random number table, Blinding description: To blind both patients and investigators, in the beginning, cans containing curcumin supplement and placebo were coded as A and B by a person other than the researcher to ensure the researcher and participants were not informed about the types of supplement received by participants. 2-3 Sepsis. Intervention 1: Intervention group: Patients receiving two 500 mg capsules of curcumin-piperine per day for 7 days (total 1000 mg of curcumin per day and 10 mg of piperine per day) (33 patients). Intervention 2: Control group: Intervention group: Patients receiving 2 placebo capsules for each day containing 500 mg of maltodextrin per day (total 1000 mg of maltodextrin) (33 patients) for 7 days. Yes - There is a plan to make this available What will be shared: All data can be shared at the request of individuals When: Six months after publishing the results. To whom: Academic researchers Conditions: Scientific uses Where to obtain: By sending an email to the following address that belongs to the executor of the project alikiaiib@med.mui.ac.ir How to obtain: Clear request on the site to access the data by the individual and then review the request by the research assistant within 2 weeks and then allow access to the data. Comments: