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IRCT20180609040016N3 IRCT 2020-12-08 Shiraz University of Medical Sciences Evaluation the effect of Plantago major L. in second degree burn wound healing Evaluation the effectiveness of treatment Plantago major L. in second degree burn wound healing 2020-03-20 anticipated 15 Complete https://irct.ir/trial/52684 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization is done by blocked randomization method with double blocks and the order of the blocks is random. Randomization of blocks is done using a table of random numbers and the allocation of treatment for patients is based on the final order of the blocks and the order of the groups within each block, Blinding description: Patients are explained about Plantago major L. ointment and all patients are informed and their details are recorded in the prepared questionnaire, but according to the type of dressing use; Plantago major L. or silver sulfadiazine are blind, the method, form and appearance of the dressing are the same in both groups and is performed by two trained and specific nurses who are related to the blind research project. The wounds evaluated by a specialist doctor who does not know the type of dressing and is blind like a investigator. 2 Evaluation the effectiveness of Plantago Major L. in second degree burn wound healing. Intervention 1: Intervention group: Hospitalized patients with second degree burn wound with an area of ​​5% or less, first irrigated with sterile normal saline and then with the dressing of Plantago major L. plant, made by Shiraz School of Pharmacy; The leaves of Plantago major L. plant are ground into a fine powder with a mill, then added with a ratio of 1/20 of sterile water and placed in a hotplate for three hours. After cooling, pass through a suitable filter and the extract is frozen and dried, then with a concentration of 10%. It is placed in Vaseline. Patients are dressed once a day until the wound heals. Intervention 2: Control group: dressing with silver sulfadiazine ointment (standard medical treatment) with the same method as the intervention group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.
public Hossein Moradi Sarvestan
Sadra Blvd.
Shiraz Iran (Islamic Republic of) 7198754361 +98 71 3622 3418 Hosseinmoradisarvestani0003@gmail.com Shiraz University of Medical Sciences scientific Abdolkhalegh Keshavarzi
Amiralmomenin hospital, Sadra Blvd
Shiraz Iran (Islamic Republic of) 7198754361 +98 71 3614 6100 Keshavarzg@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Patients with second degree burn wound Patients between 18 and 60 years old Burn case area 5% or less than 5% Less than one day burn passed Burn sources: flame or hot liquids Body mass index more than 18 and less than 25 18 years 60 years Both Do not have skin diseases and skin allergies to herbal medicines Don't have hepatic, renal, respiratory or cardiovascular diseases Don't have malignancy, immune deficiency, anemia, poisoning, Trauma, Diabetes mellitus, joint injury or involvement. Don't have pregnancy T21.2 Burn of second degree of trunk Treatment - Drugs Treatment - Drugs Intervention group: Hospitalized patients with second degree burn wound with an area of ​​5% or less, first irrigated with sterile normal saline and then with the dressing of Plantago major L. plant, made by Shiraz School of Pharmacy; The leaves of Plantago major L. plant are ground into a fine powder with a mill, then added with a ratio of 1/20 of sterile water and placed in a hotplate for three hours. After cooling, pass through a suitable filter and the extract is frozen and dried, then with a concentration of 10%. It is placed in Vaseline. Patients are dressed once a day until the wound heals. Control group: dressing with silver sulfadiazine ointment (standard medical treatment) with the same method as the intervention group Wound healing time. Timepoint: Daily once. Method of measurement: Inspection and Photographic stereology method. Pain relief. Timepoint: Daily. Method of measurement: Visual Analogue Scale. Wound infection control. Timepoint: Days 1,3,7,10,13,21. Method of measurement: Wound Culture. Shiraz University of Medical Sciences Approved 2019-11-23 Ethics committee of Shiraz University of Medical sciences Shiraz University of Medical sciences, Zand Ave. Shiraz Fars Iran (Islamic Republic of)