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IRCT20201201049555N1 IRCT 2020-12-06 Mashhad University of Medical Sciences Evaluate the effectiveness of ozone therapy on recuperation of patient suffering from Medication-related osteonecrosis of the jaw Evaluate the effectiveness of ozone therapy on recuperation of patient suffering from Medication-related osteonecrosis of the jaw 2019-11-13 anticipated 28 Complete https://irct.ir/trial/52697 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Simple randomization. A random sequence is used after using the convenience sampling method. The questionnaire is filled for all referring people on different days of the week until completion the sample size. Then we name the groups A and B, then we put a questionnaire in group A and one in the group , Blinding description: The statistical analyst and the Investigator is different from the surgeon and does not know how to treat (check the recovery rate and clinical symptoms) will be unaware of the intervention and control groups. 0 (exploratory trials) Osteonecrosis. Intervention 1: Intervention group: Ozone therapy with surgery for patients with drug-induced osteonecrosis of the jaw. Intervention 2: Control group: Traditional debridement and surgery for patients with drug-induced jaw osteonecrosis. Yes - There is a plan to make this available What will be shared: email When: starting 6 months after publication To whom: email Conditions: researchers Where to obtain: email How to obtain: Sending files via email Comments:
public Farnaz Dehabadi
Ghaem Hospital, Ahmad Abad AVE
Mashhad Iran (Islamic Republic of) 99199-91766 +98 51 3841 3492 eshghpourm@gmail.com Mashhad University of Medical Sciences scientific Farnaz Dehabadi
Ghaem Hospital, Ahmad Abad AVE
Mashhad Iran (Islamic Republic of) 99199-91766 +98 51 3841 3492 DehabadiF961@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Exposed bone or bone that can be probed through an intraoral or extraoral fistula that remains in the maxillofacial region for more than 8 weeks. No history of radiotherapy Possibility of frequent visits for ozone therapy sessions no limit no limit Both Existence of pathological fractures while entering the study Pregnant patients Poor prognosis of cancer (with five-year SR less than 10%) Incidence of pathological fractures in the jaw in the affected area Perform radiotherapy during the treatment process M87.1 Osteonecrosis due to drugs Treatment - Drugs Treatment - Drugs Intervention group: Ozone therapy with surgery for patients with drug-induced osteonecrosis of the jaw Control group: Traditional debridement and surgery for patients with drug-induced jaw osteonecrosis Tenderness pain. Timepoint: After intervention. Method of measurement: Examination. Mashhad University of Medical Sciences Approved 2019-11-13 Ethics committee of Mashhad University of Medical Sciences Ghaem Hospital, Ahmad Abad AVE Mashhad Razavi Khorasan Iran (Islamic Republic of)