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IRCT20200825048515N18 IRCT 2021-01-01 Esfahan University of Medical Sciences The effect of fentanyl and sufentanil in combination with propofol on changes in heart rate and blood pressure after laryngoscopy and endotracheal intubation The effect of fentanyl and sufentanil in combination with propofol on changes in heart rate and blood pressure after laryngoscopy and endotracheal intubation 2020-11-21 anticipated 96 Complete https://irct.ir/trial/52871 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: To blind the study, the drugs will be prepared by an anesthesiologist before the intervention. In terms of the amount of the drug, all drugs will be reached the same volume using distilled water. These syringes will be coded and placed in the operating room and delivered daily to the anesthesiologist, who will prescribe them without knowing the type of medication. Also, the patient, the person recording the clinical and basic information of the patients as well as the statistical analyst will not be aware of the type of intervention. 3 Patients under general anesthesia require endotracheal intubation. Intervention 1: Control group: In this group for patients, induction of anesthesia with normal saline at the time of induction of anesthesia with lidocaine 1.5 mg/kg, propofol 2 mg/kg with atracurium 0.6 mg/kg is performed. Intervention 2: Intervention group 1: In this group for patients, induction of anesthesia with fentanyl 3 μg/kg at the time of induction of anesthesia with lidocaine 1.5 mg/kg, propofol 2 mg/kg with atracurium 0.6 mg/kg is performed. Intervention 3: Intervention group 2: In this group for patients, induction of anesthesia with sufentanil 0.3 μg / kg during induction of anesthesia with lidocaine 1.5 mg/kg, propofol 2 mg/kg with atracurium 0.6 mg/kg is performed. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Azim Honarmand
Anesthesiology Department, Al-Zahra Hospita, Sefeh Blvd., Tohid Street
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 honarmand@med.mui.a.ir Esfahan University of Medical Sciences scientific Azim Honarmand
Anesthesiology Department, Al-Zahra Hospita, Sefeh Blvd., Tohid Street
Isfahan Iran (Islamic Republic of) 8174675731 +98 31 3620 2020 honarmand@med.mui.a.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Age range between 18-65 years, American Society of Anesthesiologists (ASA) classification equal to I or II General anesthesia candidates require endotracheal intubation 18 years 65 years Both Having kidney, liver, heart, or lung failure Addiction Having an airway abnormality Being allergic to the drugs under study Placebo Treatment - Drugs Treatment - Drugs Control group: In this group for patients, induction of anesthesia with normal saline at the time of induction of anesthesia with lidocaine 1.5 mg/kg, propofol 2 mg/kg with atracurium 0.6 mg/kg is performed. Intervention group 1: In this group for patients, induction of anesthesia with fentanyl 3 μg/kg at the time of induction of anesthesia with lidocaine 1.5 mg/kg, propofol 2 mg/kg with atracurium 0.6 mg/kg is performed. Intervention group 2: In this group for patients, induction of anesthesia with sufentanil 0.3 μg / kg during induction of anesthesia with lidocaine 1.5 mg/kg, propofol 2 mg/kg with atracurium 0.6 mg/kg is performed. Heart beat. Timepoint: Immediately before, 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Monitoring device. Blood pressure. Timepoint: Immediately before, 1, 3, 5 and 10 minutes after laryngoscopy. Method of measurement: Monitoring device. Isfahan University of Medical Sciences Approved 2020-10-17 Ethics committee of Isfahan University of Medical Sciences Street address Isfahan University of Medical Sciences, Hezar Jarib Ave., Azadi Sq Isfahan Isfehan Iran (Islamic Republic of)