IRCT20201212049683N1 IRCT 2021-01-03 Raha Pharmaceutical Company Relative bioavailability comparison of Alprazolam 0.5mg tablet formulations Relative bioavailability comparison of Alprazolam 0.5mg tablet formulations in healthy adult male volunteers under fasting conditions 2021-01-20 anticipated 24 Complete https://irct.ir/trial/52946 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Crossover, Purpose: Health service research, Randomization description: Simple randomization is done individually, using a sealed envelope. The code of the volunteers and the Test and Control group is placed in the envelope by the researcher and distributed randomly on the day of the experiment without the knowledge of the volunteer and the clinical caregiver, Blinding description: Volunteers, project partners, physicians,nurses, and those responsible for the initial data collection and analysis of data, are only unaware of the date of receipt of the sample or reference drug. Volunteers code and and tha date of receipt of the sample or reference is determined by the researcher. Volunteers, project partners, physicians , nurses, and those responsible for the initial data collection and analysis of data, are aware of the type of drug and its manufacturer. Bioequivalence Relative bioavailability. Intervention 1: Intervention group 1: Two tablets of Raha pharmaceutical company alprazolam 0.5 mg simultaneously. Intervention 2: Intervention group 2: Two tablets of Pfizer pharmaceutical company alprazolam 0.5 mg simultaneously. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is under consideration