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IRCT20101130005280N35 IRCT 2020-12-28 Mashhad University of Medical Sciences The effect of mechanical ventilation during abdominal cancer surgery in improving pulmonary complications Evaluation the effect of mechanical ventilation with a tidal volume of 10 ml / kg and 6 ml / kg during abdominal cancer surgery on the rate of compliance and airway resistance of patients 2020-11-21 anticipated 90 Complete https://irct.ir/trial/53215 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Simple randomization with table of random numbers available at ''www.randomization.com'' website will be used. Numbers will be placed in sealed envelopes and each envelope is assigned to one participant placing them in one of the two groups, Blinding description: In this study, participants are not aware of the intervention. Also, outcome assessors are unaware of how patients are grouped, although patients are aware of the project after receiving full explanations and even an invitation from the patients' families, but they do not know which group they are in. 3 abdomen cancer. Intervention 1: Intervention group: In the intervention group, after anesthesia in abdominal cancer surgery and manual ventilation with a mask 8-10 times per minute and passed 2 minutes when the patient's jaw is relaxed the patient is intubated and after confirmation of the patient's tube Correct location, ventilation or auxiliary mechanical ventilation for the patient is done. Mechanical ventilation is performed with a positive end-expiratory pressure (8 breaths = 5 peeps) and a high current volume of 10 ml / kg. Mechanical ventilation is an essential support method for maintaining adequate gas exchange during general anesthesia, which prevents postoperative complications, hypoxemia, and improves lung function. Intervention 2: Control group: In this group, after anesthesia in abdominal cancer surgery and manual ventilation with a mask 8-10 times per minute and after 2 minutes when the patient's jaw is relaxed, the patient is intubated and after confirmation of the patient's tube Correct location ventilation or auxiliary mechanical ventilation for the patient is done.Mechanical ventilation is performed with positive end-expiratory pressure (number of breaths 14 with Peep = 5) and low volume at 6 ml / kg. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Relevant partners should be consulted on how to publish
public Majid Razavi
Ebne Sina St., Imam Reza Hospital
Mashhad Iran (Islamic Republic of) ٩١٣٧٩١٣٣١۶ +98 51 3854 3031 RazaviM@mums.ac.ir Mashhad University of Medical Sciences scientific Majid Razavi
Ebne Sina St., Imam Reza Hospital
Mashhad Iran (Islamic Republic of) ٩١٣٧٩١٣٣١۶ +98 51 3854 3031 RazaviM@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Candidate for elective abdominal surgery due to cancer People in the age range of 65-65 years 20 years 65 years Both Other diseases such as chronic lung disease like asthma and COPD and heart disease or kidney failure Existence of other concomitant surgeries such as thoracic surgery History of previous lung surgery D21.4 Benign neoplasm of connective and other soft tissue of abdomen Prevention Prevention Intervention group: In the intervention group, after anesthesia in abdominal cancer surgery and manual ventilation with a mask 8-10 times per minute and passed 2 minutes when the patient's jaw is relaxed the patient is intubated and after confirmation of the patient's tube Correct location, ventilation or auxiliary mechanical ventilation for the patient is done. Mechanical ventilation is performed with a positive end-expiratory pressure (8 breaths = 5 peeps) and a high current volume of 10 ml / kg. Mechanical ventilation is an essential support method for maintaining adequate gas exchange during general anesthesia, which prevents postoperative complications, hypoxemia, and improves lung function. Control group: In this group, after anesthesia in abdominal cancer surgery and manual ventilation with a mask 8-10 times per minute and after 2 minutes when the patient's jaw is relaxed, the patient is intubated and after confirmation of the patient's tube Correct location ventilation or auxiliary mechanical ventilation for the patient is done.Mechanical ventilation is performed with positive end-expiratory pressure (number of breaths 14 with Peep = 5) and low volume at 6 ml / kg Compliance rate. Timepoint: At the beginning of the study (before the intervention) and 2 hours after the surgery. Method of measurement: Ventilator. Airway resistance. Timepoint: At the beginning of the study (before the intervention) and 2 hours after the surgery. Method of measurement: Ventilator. Mashhad University of Medical Sciences Approved 2020-05-27 Ethics Committee of Mashhad University of Medical Sciences Daneshgah street, Ghoreishi building Mashhad Razavi Khorasan Iran (Islamic Republic of)