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IRCT201010194970N1 IRCT 2010-12-12 Mazandaran University of Medical Sciences Ginger efficacy in patients uncontrolled on standard moderate asthma treatment Ginger efficacy in patients uncontrolled on standard moderate asthma treatment: a randomized, double-blind, placebo-controlled, cross-over study 2010-11-22 anticipated 40 Complete https://irct.ir/trial/5331 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment. N/A Asthma. Intervention 1: Type of intervention: Ginger powder, oral 250 mg capsule, three times daily for 10 weeks. Intervention 2: Control group: Placebo.
public Dr. Nazanin Mansouri
Amir Mazandarani Street, Emam Hospital
Sari Iran (Islamic Republic of) 4816633131 +98 15 1226 1700 mansourinazanin@yahoo.com School of Medicine, Mazandaran University of Medical Sciences scientific Dr. Davood Farzin
Darya Street, Mazandaran University of Medical Sciences, School of Medicine
Sari Iran (Islamic Republic of) P.O. box: 481751665 +98 15 1354 3088 davoodfarzin@yahoo.com School of Medicine, Mazandaran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: 40 consenting non-smoking patients aged between 16 and 70 years with a documented positive bronchodilator reversibility test with ≥ 15% improvement in FEV1 from 15 to 30 minutes after inhalation of at least 200 μg of salbutamol are enrolled in the 10-week, randomized controlled cross over study. Exclusion criteria for the study are: emergency treatment for an asthma exacerbation within one month, COPD, upper airway infections in the last three weeks, hospitalization for asthma in the three months previous to enrolment, treatment with antihistamines, anticholinergics, theophyline and chromones, oral corticosteroids and β2 agonists, presence of autoimmune, cardiac, hepatic or renal disorders, malabsorption, drug-addiction, pregnancy and lactation. 16 years 70 years Both J45 Moderate asthma Treatment - Drugs Placebo Type of intervention: Ginger powder, oral 250 mg capsule, three times daily for 10 weeks Control group: Placebo Spirometric tests. Timepoint: Weeks 1, 3, 5, 6, 8, 10. Method of measurement: Spirometry apparatus. Immunologic tests. Timepoint: Weeks 1, 3, 5, 6, 8, 10. Method of measurement: laboratorial evaluation of IgE and sputum eosinophil. Condition of asthma control. Timepoint: Weeks 1, 3, 5, 6, 8, 10. Method of measurement: Clinical memoir, physical examination, completion of asthma control questionnaires. Side effect of drugs. Timepoint: weeks 1, 3, 5, 6, 8, 10. Method of measurement: Clinical memoir, Physical examination. Mazandaran University of Medical Sciences Approved 2010-05-26 Mazandaran University of Medical Sciences Moallem Street, Moallem Square Sari Iran (Islamic Republic of)