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IRCT20201227049857N1 IRCT 2021-02-19 Tabriz University of Medical Sciences The effect of astaxanthin supplementation in patients with coronary artery disease The effects of Astaxanthin supplementation on serum levels of Sirtuin1، TNF-α، metabolic parameters, body composition and nutritional status in patients with coronary artery disease. 2021-02-17 anticipated 44 Complete https://irct.ir/trial/53317 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Individuals of the two groups will be placed in one of the intervention or control groups, which will be based on blocks created by random allocation software. The random sequence generated is kept in a safe place and performed by an independent person who is blind to the trial during the study, Blinding description: During the study, neither participants nor researchers will know that each person is in the intervention or control group. 3 Coronary Artery Disease. Intervention 1: Intervention group:. Intervention 2: Control group:. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Marzieh heidari
Golgasht street, Tabriz university of medical sciences
Tabriz Iran (Islamic Republic of) 5166614711 +98 41 3381 1902 Mheidari.95@yahoo.com Tabriz University of Medical Sciences scientific Dr mohammad alizadeh
Golgasht street, Tabriz university of medical sciences
Tabriz Iran (Islamic Republic of) 5166614711 +98 41 3335 7581 mdalizadeh@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) age between 65-40 years BMI between 25-35 Proof of 50% stenosis in at least one of the major coronary arteries in angiography Ability, and willingness to collaborate on the project 40 years 65 years Both Smoking, alcohol and hookah consumption Hypothyroidism and Hyperthyroidism Uncontrolled diabetes History of myocardial infarction Cardiac dysfunction (Class 3 and 4) Valvular heart disease Kidney failure Pregnant and lactating women Taking herbal supplements and antioxidants in the last three months Treatment - Drugs Treatment - Drugs Intervention group: Control group: Serum level of Sirtuin1. Timepoint: At the beginning and end of the study after 8 weeks. Method of measurement: Measurement with ELISA kit. Serum level TNF-∝. Timepoint: At the beginning and end of the study after 8 weeks. Method of measurement: Measurement with ELISA kit. Lipid profile. Timepoint: At the beginning and end of the study after 8 weeks. Method of measurement: Enzyme kits and the Friedwald equation. Glycemic indexes. Timepoint: At the beginning and end of the study after 8 weeks. Method of measurement: ELISA and spectrophotometer. Anthropometric Indices. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: Measurement of height and weight without shoes and with minimum clothes on, by Seca stadiometer and scale, respectively. Measurement of the waist and hip circumference by a tape measure and body mass index (BMI) by dividing weight (kg) by height squared (m2) and measurement of body composition. Oxidative stress indices. Timepoint: At the beginning and end of the study after 8 weeks. Method of measurement: Measurement of serum levels of Total antioxidant capacity (TAC) and malondialdehyde (MDA) and Superoxide dismutase by spectrophotometry. Plasminogen activator inhibitor-1. Timepoint: At the beginning and end of the study after 8 weeks. Method of measurement: Measurement with ELISA kit. Physical activity level. Timepoint: At the begening and end of the intervention. Method of measurement: Via IPAQ questionnaire. Quality of life. Timepoint: At the beginning and end of the study after 8 weeks. Method of measurement: Via MacNew questionnaire. Depression severity. Timepoint: At the beginning and end of the study after 8 weeks. Method of measurement: Beck Depression Inventory scale. Blood pressure. Timepoint: At the beginning and end of the study after 8 weeks. Method of measurement: Using a mercury barometer. Tabriz University of Medical Sciences Approved 2021-02-16 Ethics committee of Tabriz University of Medical Sciences Tabriz University of Medical Sciences, Attar Neyshabouri Av., Golgasht St. Tabriz East Azarbaijan Iran (Islamic Republic of)