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IRCT20190325043107N20 IRCT 2020-12-31 Tabriz University of Medical Sciences ketorolac + low dose pethidine comparison with pethidine after elective laparotomy leading to colectomy Assessing analgesia in mixed administrations of ketorolac + low dose pethidine comparison with pethidine after elective laparotomy leading to colectomy 2021-01-19 anticipated 100 Complete https://irct.ir/trial/53382 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Patients will be divided into two groups by random allocation method. The balanced (permuted) block randomization will be used for random allocation and patients will be divided into two groups of ketorolac + pethidine and pethidine ; Thus, first 6 possible modes of blocks (BAAB, ABBA, BABA, AABB, ABAB, BBAA) were listed and each block was assigned a number from 1 to 0. Then, a number between 1 and 0 was randomly selected and the subjects were assigned to the experimental group (A) and placebo (B) based on the relevant block and the selected number. 2-3 Pain. Intervention 1: Intervention group: Patients will be randomly assigned to this group and will receive ketrolac (4 mg) + pethidine (40 mg) intravenously every 8 hours after elective colectomy; The severity of the pain will then be measured using a VAS instrument every eight hours. Intervention 2: Intervention group: Intervention group: Patients will be randomly assigned to this group and will receive pethidine (40 mg) intravenously every 8 hours after elective colectomy; The severity of the pain will then be measured using a VAS instrument every eight hours. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Mehdi Khanbabayi Gol
Imam Reza Hospital, Azadi Ave
Tabriz Iran (Islamic Republic of) 5981764863 +98 41 3334 7054 Khanbabayimehdi69@gmail.com Tabriz University of Medical Sciences scientific Mehdi Khanbabayi Gol
Imam Reza Hospital, Azadi Ave
Tabriz Iran (Islamic Republic of) 5165665631 +98 41 3334 7054 Khanbabayimehdi69@gmail.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Weight between 45 to 115 kg Candidate elective laparotomy leading to colectomy no limit no limit Both Getting gastritis Having unknown bleeding disorders Pregnant women Opioid addiction G89.29 Other chronic pain Treatment - Drugs Treatment - Drugs Intervention group: Patients will be randomly assigned to this group and will receive ketrolac (4 mg) + pethidine (40 mg) intravenously every 8 hours after elective colectomy; The severity of the pain will then be measured using a VAS instrument every eight hours. Intervention group: Intervention group: Patients will be randomly assigned to this group and will receive pethidine (40 mg) intravenously every 8 hours after elective colectomy; The severity of the pain will then be measured using a VAS instrument every eight hours. Pain. Timepoint: The intervention will start immediately after the end of the surgery and will continue for up to two days after the surgery. The study variable will be measured every six hours from the beginning of the study for three days with the help of VAS instrument. Method of measurement: VAS. Tabriz University of Medical Sciences Approved 2020-01-20 Ethics committee of Tabriz University of Medical Sciences Tabriz University of Medical Sciences, Azadi Ave Tabriz East Azarbaijan Iran (Islamic Republic of)