IRCT20160523028008N8 IRCT 2021-01-22 Hamedan University of Medical Sciences Treatment of respiratory distress syndrome in preterm infants A randomized trial comparing surfactant administration using InSurE technique and the minimally invasive surfactant therapy in preterm infants at the age of 28 to 36 weeks of gestation and respiratory distress syndrome 2019-11-22 anticipated 112 Complete https://irct.ir/trial/53461 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients will be randomly assigned to the intervention and control groups using block randomization. The patients will be randomly assigned to the intervention and control groups using block randomization. Arrangement of the randomization process: 1) Determining the volume of each block (quadruple blocks) 2) Preparing the list of the blocks and assigning a number (between 1 and 6 ) to each of them 3)Choosing random numbers between 1 and 6 4) Defining the treatment assignment list, Blinding description: The person evaluating the outcome will be unaware of the type of intervention. 2-3 Neonatal respiratory distress syndrome. Intervention 1: Intervention group:Participants take 200 mg/kg surfactant (Curosurf Chiesi Farmaceutici, Parma, Italy)by MIST method. Neonatal intubation and who are receiving2000 mg/kg surfactants in 1-3 minutes via feeding tube. Intervention 2: Intervention group: Participants take 200 mg/kg surfactant (Curosurf Chiesi Farmaceutici, Parma, Italy) by INSUR method.They receive 200 mg/kg surfactant in 1-3 minutes from a feeding tube via a thin intratracheal catheter (Insure method) during spontaneous breathing. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information"