IRCT20110530006640N8 IRCT 2021-03-07 Tehran University of Medical Sciences Intrauterine Instillation of Tranexamic Acid in Hysteroscopic Myomectomy The Effect of Intrauterine Instillation of Tranexamic Acid on Postoperative Hemoglobin in Hysteroscopic Myomectomy 2021-03-21 anticipated 70 Complete https://irct.ir/trial/53490 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: For randomization, we will use the block randomization method that will be designed by the epidemiologist using STATA software, version 13. The number of blocks is considered to be 6. The random allocation list will be only available to the operation room nurse. To conceal the random allocation process, 70 treatment cards written in order, will be placed in sealed envelopes. When the surgeon determines the patient's eligibility, the nurse opens the envelope related to the type of intervention and determines the type of media that should be used for the patient according to the contents of the envelope and provides it to the surgeon's assistant, who has no role in conducting the research, Blinding description: Occasionally, normal saline is used at room temperature as a distending medium in this surgery, which will also be used in the control group. In the intervention group, 0.5 g of tranexamic acid ampoule per 1000 cc of distending medium will be dissolved and used. The surgeon is not aware of the presence of tranexamic acid in the distending medium and immediately after the surgery will record study variables without knowing the type of medium used; Therefore, the surgeon, the patient, and the outcome assessor (the surgeon) are not aware of the type of media and intervention. Also, for data analysis, a statistician who is separate from the study process and is unaware of all the processes will perform analyses. Also, a statistical expert who is not aware of the type of interventions will analyze the data. 3 Submucous leiomyoma of uterus. Intervention 1: Intervention group: In the intervention group, tranexamic acid ampoule with a dose of 0.5 g per 1000 cc of normal saline distending medium will be used (considering that the injection dose is 1 gram and can be repeated every 6 to 8 hours and can be used in electrolyte solutions according to the manufacturer's instructions). (Manufactured by Caspian Tamin Pharmaceutical). Intervention 2: Control group: In the control group, according to the routine, only normal saline will be used as distending medium. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No decision has been made yet.