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IRCT20210110049997N1 IRCT 2021-06-04 Kashan University of Medical Sciences The effect of vaginal sildenafil on endometrial thickness and pregnancy rates in infertile women The effect of vaginal sildenafil on endometrial thickness and pregnancy rates in infertile women undergoing intrauterine insemination 2021-03-16 anticipated 60 Complete https://irct.ir/trial/53619 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The subjects were randomly divided into two groups of 30 people receiving sildenafil and estradiol (experimental group) and the group receiving estradiol (control group). In this method, a number of cards selected by the researcher as the first group and the same number of cards for the next groups are considered; Then, by merging the cards together (flipping the cards), a card is taken out and its allocation is recorded, and that card is returned to the other cards after being taken out. The cards are then merged again and another card is removed. This process continues until a random sequence according to the sample size is reached. 3 Female infertility. Intervention 1: Intervention group: Sildenafil and estradiol, made in Iran and Marham Daroo Company, a vaginal tablet of sildenafil 25 mg and an oral tablet of estradiol 2 mg every 12 hours are prescribed every 6 hours. Intervention 2: Control group: Estradiol 2 mg tablets are given every 12 hours until the day of HCG (human chorionic gonadotropin) injection. Yes - There is a plan to make this available What will be shared: Part of the data, such as information about the main outcome, can be shared. When: Access period starts from 1400 To whom: Researchers working in academic and scientific institutions Conditions: Request in writing and signed by mail Where to obtain: Mainly responsible for the study How to obtain: Request and provide information Comments:
public Niloofar Mehry
No. 32, 24 metri taro pood alley, elahie Blvd, Kashan Town
Kashan Iran (Islamic Republic of) 8719860004 +98 31 5554 0026 niloofar.mehry.1988@gmail.com Kashan University of Medical Sciences scientific Niloofar Mehry
No. 32, 24 metri taro pood alley, elahie Blvd, Kashan Town
Kashan Iran (Islamic Republic of) 8719860004 +98 31 5554 0026 niloofar.mehry.1988@gmail.com Kashan University of Medical Sciences Iran (Islamic Republic of) The number of sperm in female spouses is between 5-10 million. Sperm motility of female spouses should be between 25-30%. The normal morphology of female spouses sperm is between 3-4%. Women's body mass index should be less than 40. Endometrial thickness less than 7 mm. no limit 40 years Female Hypotension History of endocrine diseases History of stroke or heart attack Cardiovascular problems Consumption of nitrites or nitrates N97.9 Female infertility, unspecified Treatment - Drugs Placebo Intervention group: Sildenafil and estradiol, made in Iran and Marham Daroo Company, a vaginal tablet of sildenafil 25 mg and an oral tablet of estradiol 2 mg every 12 hours are prescribed every 6 hours. Control group: Estradiol 2 mg tablets are given every 12 hours until the day of HCG (human chorionic gonadotropin) injection. Endometrial thickness. Timepoint: Measurement of endometrial thickness at the beginning of the study (before the start of the intervention, which should be less than 7 mm) and 14 days after the start of taking an oral estradiol tablet and a sildenafil vaginal tablet. Method of measurement: Ultrasound device. Kashan University of Medical Sciences Approved 2020-09-08 Faculty of Medicine and Dentistry - Kashan University of Medical Sciences Kashan-Qutb Ravandi Boulevard-Kashan University of Medical Sciences Kashan Isfehan Iran (Islamic Republic of)