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IRCT20180120038450N4 IRCT 2022-04-03 Kermanshah University of Medical Sciences Design, fabrication and evaluation of physical and chemical properties and evaluation of the clinical effect of formulation of targeted cerebral drug delivery system through the nose containing Sumatriptan in acute migraine attacks Design, fabrication and evaluation of physical and chemical properties and evaluation of the clinical effect of formulation of targeted cerebral drug delivery system through the nose containing Sumatriptan in acute migraine attacks 2022-02-20 anticipated 73 Complete https://irct.ir/trial/53647 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Crossover, Purpose: Treatment. 3 Acute migraine attack. Intervention 1: Group 1: 37 people are non randomized selected and use Sumatriptan nasal spray(10mg) in the first two migraine attacks and Sumatriptan oral tablet (50mg)in the next two attacks. Intervention 2: The second group: 36 people are randomly selected and in the first two migraine attacks they use Sumatriptan oral tablet(50mg) and in the next two attacks they use Sumatriptan nasal spray(10mg). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Azar mollaei
Bustan Girls' Dormitory 2-Nurse Boulevard, in front of Imam Reza Hospital
kermanshah Iran (Islamic Republic of) 6714438621 +98 87 3352 2321 azar_mollaei_98@yahoo.com Kermanshah University of Medical Sciences scientific shahla mirzaei
Faculty of Pharmacy-Parstar Blvd-Daneshgah St-Shahid Shiroodi Blvd
kermanshah Iran (Islamic Republic of) 6714415153 +98 83 3426 6780 shahlamirzaeei@gmail.com Kermanshah University of Medical Sciences Iran (Islamic Republic of) Patients with 2 to 8 migraine attacks per month History of more than one year with migraine(with aura or without aura) 18 years 50 years Both Pregnancy History of high blood pressure History of myocardial infarction History of stroke Allergy to sumatriptan History of coronary artery disease History of congenital heart disease Cardiovascular disease Pulmonary disease Cardiac arrhythmias Angina Cerebrovascular disease G43 Migraine Treatment - Drugs Treatment - Drugs Group 1: 37 people are non randomized selected and use Sumatriptan nasal spray(10mg) in the first two migraine attacks and Sumatriptan oral tablet (50mg)in the next two attacks. The second group: 36 people are randomly selected and in the first two migraine attacks they use Sumatriptan oral tablet(50mg) and in the next two attacks they use Sumatriptan nasal spray(10mg). Migraine headache condition. Timepoint: Before the intervention and a month later. Method of measurement: Visual Analogue Scale/Headache Impact Test. Adverse effect. Timepoint: At the onset of a migraine attack up to two hours after taking the drug. Method of measurement: Side effects questionnaire. Kermanshah University of Medical Sciences Approved 2022-01-03 Ethics committee ofkermanshah University of Medical Sciences Central Organization of Kermanshah University of Medical Sciences-Shahid Beheshti Blvd Kermanshah Kermanshah Iran (Islamic Republic of)