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IRCT20201212049681N1 IRCT 2021-02-28 Shiraz University of Medical Sciences Evaluating the effect of gargling with Hydrogen Peroxide 1% and Povidine Iodine 0.25% on viral load of SARS-CoV-2 in covid19 patients SARS-COV2, Covid19 Evaluating the effect of gargling with Hydrogen Peroxide 1% and Povidine Iodine 0.25% on viral load of SARS-CoV-2 in covid19 patients ; A pilot randomized clinical trial 2021-01-20 anticipated 60 Complete https://irct.ir/trial/53702 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients Will be equally divided into three experimental groups, namely, the A,B,C group. The allocation of the participants will be based on the block randomization method using the online RANDOM.ORG software. Each random number will be placed in a sealed opaque envelope and subsequently, each participant randomly will pick one envelope corresponding to either the A,B, orC group, Blinding description: To ensure both the participants and clinicians will be blinded to the clinical trial,all the participants, the nurse which will do the sampling and the author will be blinded from each other, and are not aware of the mouthwash that is used. 3 Covid-19. Intervention 1: intervention group: Group A (n=20) patients on 10 ml gargle using 0.25% Povidone-Iodine, for 20-30 seconds,. Intervention 2: intervention group: Group B (n=20) patients will be subjected to 10 ml gargle using 1% Hydrogen peroxide for 20-30 seconds. Intervention 3: Control group: Group C (n=20) will serve as positive control. These will be given simple normal saline gargles for 20-30 seconds,. Yes - There is a plan to make this available What will be shared: the main outcome information When: starting 6 months after the publication To whom: academic and industrial investigators Conditions: academic and industrial investigators Where to obtain: adla@sums.ac.ir How to obtain: after the investigation Comments:
public Zahra Rajabzadeh
Department of Endodontics, School of Dentistry, Ghasrdast Street, Shiraz, Iran,
Shiraz Iran (Islamic Republic of) 71956-15878 +98 71 3832 3435 adla@sums.ac.ir Shiraz University of Medical Sciences scientific Zahra Rajabzadeh
Department of Endodontics, School of Dentistry, Ghasrdast Street, Shiraz, Iran,
Shiraz Iran (Islamic Republic of) 71956-15878 +98 71 3832 3435 adla@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) having age 18-50, those who are hospitalized and have confirmed covid 19 viral contamination. 18 years 50 years Both having any systemic disease or medications that may interact with Povidine Iodine and-or Hydrogen Peroxide patients who are not feeling well, not cooperative patients, and those who don’t want to participate in the study RAO1.0 severe acute respiratory syndrome corona virus Treatment - Drugs Treatment - Drugs Placebo intervention group: Group A (n=20) patients on 10 ml gargle using 0.25% Povidone-Iodine, for 20-30 seconds, intervention group: Group B (n=20) patients will be subjected to 10 ml gargle using 1% Hydrogen peroxide for 20-30 seconds. Control group: Group C (n=20) will serve as positive control. These will be given simple normal saline gargles for 20-30 seconds, Viral load before the intervention, viral load after the intervention. Timepoint: before intervention and 5-10 minutes after intervention. Method of measurement: real-time reverse transcriptase polymerase chain reaction (rRT-PCR). Viral transmission in saliva. Timepoint: before the intervention and 5-10 minutes after the intervention. Method of measurement: real-time reverse transcriptase polymerase chain reaction (rRT-PCR). Shiraz University of Medical Sciences Approved 2021-01-09 Ethics committee of Shiraz University Of Medical Sciences Department of Endodontics, School of Dentistry, Ghasrdast Street, Shiraz, Iran, Shiraz Fars Iran (Islamic Republic of)