IRCT20150721023282N16 IRCT 2021-03-25 Esfahan University of Medical Sciences Effect of arginine in diabetic foot ulcers Evaluation of the effect of gel containing arginine-releasing chitosan nanofibers in the healing of diabetic foot ulcers: a randomized, controlled clinical trial 2021-04-21 anticipated 22 Complete https://irct.ir/trial/53705 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization method using blocks of size 4 will be used. So that all possible sequences of two drug and two placebo in each block will be made with each block being numbered. Then, using random number table, the blocks will be selected randomly and the patients will be assigned to the two groups of drug and placebo according to the the blocks sequences. 3 diabetic foot ulcer. Intervention 1: Intervention group: Chitosan gel (the amount needed to create a layer 3 mm thick on sterile gauze and placed on the wound surface, so as to cover the entire wound surface), once a day with dressing and other routine care including Debridement, rinsing with normal saline and antibiotics will be prescribed for 2 weeks if necessary and blood sugar control. The wound will be washed before applying the gel. Intervention 2: Control group: The control group will be given a new dressing (the type of which will be determined based on the type of wound and only one of them will be included in the study) once a day and routine care for 2 weeks. No - There is not a plan to make this available Justification or reason for not sharing IPD is It is not necessary