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IRCT20101026005026N9 IRCT 2018-05-08 Iran University of Medical Sciences The Effect of desmopressin administration on intraoperative blood loss of sinus surgery The Effect of nasal spray of desmopressin administration on intraoperative blood loss and quality of the surgical field during functional endoscopic sinus surgery in patients with chronic rhino sinusitis 2017-12-22 anticipated 60 Complete https://irct.ir/trial/5371 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Other, Purpose: Treatment, Randomization description: Patients were randomly allocated to the Dessmopresin or Placebo groups. Simple Randomization was performed, using a table of random numbers, Blinding description: Patients, outcome assessor and data analyser were blinded to the assignments. N/A Bleeding during endoscopic surgery of sinuses (FESS). Intervention 1: One puff Desmopressin nasal spray (10 μg) in either nostril before anesthesia. Intervention 2: One puff nasal spray of normal saline in either nostril before anesthesia. Yes - There is a plan to make this available What will be shared: Data regarding primary and secondary outcomes will be available When: Immediately after publication To whom: Only faculty members and academic institutions Conditions: The result of further analysis may not be presented to public without permission Where to obtain: masood.mohseni@gmail.com How to obtain: A reasonable request from an academic source will be responded within 10 working days Comments:
public Masood Mohseni
Rasool Akram hospital, Niayesh Ave, Sattarkhan St
Tehran Iran (Islamic Republic of) 1445613131 +98 21 6435 2326 masood.mohseni@gmail.com Iran University of Medical Sciences scientific Masood Mohseni
Rasool Akram hospital, Niayesh Ave, Sattarkhan St
Tehran Iran (Islamic Republic of) 1445613131 +98 21 6435 2326 masood.mohseni@gmail.com Iran University of Medical Sciences Iran (Islamic Republic of) All patients must be 18–65 years old, who it is their first-time candidates for two-side FESS 18 years 65 years Both Patients with a history of bleeding disorders or taking medications that may affect surgical homeostasis; Poorly controlled hypertension or cerebrovascular disease; A history of significant coronary artery disease or arrhythmia Secondary surgery Pregnancy A compromised renal or hepatic function; and J32 Chronic sinusitis Treatment - Drugs Treatment - Drugs One puff Desmopressin nasal spray (10 μg) in either nostril before anesthesia One puff nasal spray of normal saline in either nostril before anesthesia Intraoperative blood loss. Timepoint: Every 15 minuets from the begining of anesthesia until maximum 90 minutes. Method of measurement: Final intraoperative blood loss was confirmed at the end of each procedure by accounting for loss of blood and irrigation fluid into the suction canister, and nasopharyngeal packing (measured weight of packing on the electronic scale). Quality of the surgical field during functional endoscopic sinus surgery. Timepoint: End of surgery. Method of measurement: A scoring scale adapted from Boezaart and van der merew. Bleeding after the surgery. Timepoint: Until 4 days after surgery. Method of measurement: Questionnaire. Iran University of Medical Sciences Approved 2017-12-11 Ethics committee of Iran university of medical Sciences Hemmat Highway, Iran University of Medical Sciences Tehran Tehran Iran (Islamic Republic of)