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IRCT20170514033961N7 IRCT 2021-01-23 Khoram-Abad University of Medical Sciences The effect of olive extract on arthrosis of the knee The effect of hydroalcoholic extract of olive leaf on osteoarthritis of the knee and daily functioning of the elderly 2021-01-03 anticipated 120 Complete https://irct.ir/trial/53755 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Factorial, Purpose: Supportive, Randomization description: The samples included in the study are placed in four groups using random stratified blocking method. The method of allocating 120 eligible samples in 4 groups of 30 is as follows, taking into account the sex class (male and female) and in A total of 4 floors are formed. Within each class, the method of 4 random blocks is used to assign patients to the four groups studied. To do this, first write the list of blocks and assign numbers to them (AABB (1) - ABAB (2) -ABBA (3) -BBAA (4) - BABA (5) - BAAB (6)) then using A table of random numbers will be assigned to them at random, and finally a list of treatment assignments will be formed based on a sequence of letters A and B. 2 osteoarthrit. Intervention group 1: For intervention in this group, high quality olive leaf extract ointment of coronaci species prepared by Danakasia company is provided to the research samples and they will be trained to use 15 ml of it topically in the tibiofemoral area three times a day for eight weeks. Also continue their routine treatment during the intervention period, which includes taking acetaminophen 500 mg tablets every eight hours.Intervention group 2: Capsules containing 60 mg of high quality olive leaf extract powder of Cronaci species prepared by Danacasia company will be provided to the research samples and they will be trained to take it orally with each meal three times a day for eight weeks and also during the course. Continue your routine treatment intervention, which includes taking acetaminophen 500 mg tablets every eight hours.Intervention group 3: Capsules containing high quality olive leaf extract along with ointment containing olive leaf extract prepared by Danakasiarad company are provided with research samples and they will be trained to take them orally with food every day for eight weeks and three times a day, respectively. Topically in the tibiofemoral area and also during the intervention period, continue their routine treatment, which includes taking acetaminophen 500 mg tablets every eight hours. Intervention group 4: Take routine treatment, including taking acetaminophen 500 mg tablets every eight hours, and do not use any other medicine to relieve this drug.. Yes - There is a plan to make this available What will be shared: All potential data is released after unidentifiable individuals in the form of original message information. When: The access period will start from 2021 To whom: All researchers, lecturers, medical students can receive the published article from the relevant journal. Conditions: Unidentifiable data will be made available to health researchers for the study of meta-analysis. Where to obtain: end email to Mandanasaki.m.saki@modares.ac.ir How to obtain: After sending the documents by the applicant researcher via email, the data will be sent two weeks later. Comments:
public saki mandana
No. 18, Rose Alley, Enghelab St., Lorestan, Khorramabad
Khorram abad Iran (Islamic Republic of) 6819834525 +98 66 3331 6465 mandana-saki@yahoo.com Khoram-Abad University of Medical Sciences scientific mandana saki
No. 18, Rose Alley,Enghelab St.Khorramabad, Lorestan,
KHorram abad Iran (Islamic Republic of) 6819834525 +98 66 3331 6465 mandana-saki@yahoo.com Khoram-Abad University of Medical Sciences Iran (Islamic Republic of) The individual's desire to participate in the study Being 60-80 years old Diagnosis of primary osteoarthritis of the knee Participating in the study based on the diagnosis of an orthopedic specialist (based on the description of clinical symptoms, physical examination, radiographic criteria and diagnostic properties related to the disease) Have Osteoarthritis Grade 1-3 Based on American College of Rheumatology Classification Criteria Having moderate pain according to visual analog criteria (4-7) No dependence on others in performing daily activitiesFailure to perform physiotherapy and surgery in the last 12 months No intra-articular injection of steroids in the last 6 months Having a body mass index of less than 30 Have a performance score above 34 No neurological diseases associated with movement and balance disorders 60 years 80 years Both Creating acute medical conditions The death of the elderly at the time of study Reluctance to continue participating in the study Sensitivity to olives Existence of cognitive disorders Secondary osteoarthritis in rheumatologydiseases (such as rheumatoid arthritis, gout, infectious arthritis, metabolic arthritis, traumatic arthritis) M17 Osteoarthritis of knee Rehabilitation Intervention group 1: For intervention in this group, high quality olive leaf extract ointment of coronaci species prepared by Danakasia company is provided to the research samples and they will be trained to use 15 ml of it topically in the tibiofemoral area three times a day for eight weeks. Also continue their routine treatment during the intervention period, which includes taking acetaminophen 500 mg tablets every eight hours.Intervention group 2: Capsules containing 60 mg of high quality olive leaf extract powder of Cronaci species prepared by Danacasia company will be provided to the research samples and they will be trained to take it orally with each meal three times a day for eight weeks and also during the course. Continue your routine treatment intervention, which includes taking acetaminophen 500 mg tablets every eight hours.Intervention group 3: Capsules containing high quality olive leaf extract along with ointment containing olive leaf extract prepared by Danakasiarad company are provided with research samples and they will be trained to take them orally with food every day for eight weeks and three times a day, respectively. Topically in the tibiofemoral area and also during the intervention period, continue their routine treatment, which includes taking acetaminophen 500 mg tablets every eight hours. Intervention group 4: Take routine treatment, including taking acetaminophen 500 mg tablets every eight hours, and do not use any other medicine to relieve this drug. Knee pain score. Timepoint: The beginning of the study, the second, fourth, sixth, eighth week. Method of measurement: Visual Analog Scale,. Joint dryness score. Timepoint: The beginning of the study, the second, fourth, sixth, eighth week. Method of measurement: Osteoarthritis Index of West Ontario University and McMaster. Psychological performance score. Timepoint: The beginning of the study, the second, fourth, sixth, eighth week. Method of measurement: Osteoarthritis Index of West Ontario University and McMaster. Khoram-Abad University of Medical Sciences Approved 2021-01-17 Ethics Committee of Lorestan University of Medical Science Vice Chancellor for Research and Technology, Lorestan, Khorramabad, Road, Pardis University Complex University of Medical Sciences, KHorramabd Lorestan Iran (Islamic Republic of)