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IRCT20200217046523N10 IRCT 2021-02-04 Esfahan University of Medical Sciences The effect of preoperative use of celecoxib , gabapentin , combination of celecoxib with gabapantin and combination of celecoxib with dexamethasone and gabapantin on postoperative pain relief Evaluation and comparison of the effect of preoperative use of celecoxib , gabapentin , combination of celecoxib with gabapantin and combination of celecoxib with dexamethasone and gabapantin in reducing postoperative pain in patients undergoing total knee replacement surgery 2021-02-18 anticipated 144 Complete https://irct.ir/trial/53776 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Total Knee Arthroplasty. Intervention 1: Intervention group 1: Patients in this group are treated with two doses of 400 mg celecoxib alone before surgery and their pain will be assessed by analog visual criteria at 24, 48 and 72 hours after surgery. Intervention 2: Intervention group 2: Patients in this group are treated with two doses of 300 mg of gabapentin alone before surgery and their pain will be assessed by visual analog criteria at 24, 48 and 72 hours after surgery. Intervention 3: Intervention group 3: Patients in this group, in addition to 400 mg celecoxib, are treated with two doses of 300 mg gabapentin before surgery and their pain will be assessed by visual analog criteria at 24, 48 and 72 hours after surgery. Intervention 4: Intervention group 4: Patients in this group, in addition to celecoxib 400 mg and gabapentin 300 mg, will also receive two doses of dexamethasone 4 mg before surgery and their pain will be assessed by visual analog criteria at 24, 48 and 72 hours after surgery. Yes - There is a plan to make this available What will be shared: All data can be shared after people have requested. When: Six months after publishing the results. To whom: Academic researchers Conditions: Scientific uses Where to obtain: Isfahan University of Medical Sciences website How to obtain: Clear request on the site to access the data by the individual and then review the request by the research assistant within 2 weeks and then allow access to the data. Comments:
public Mehdi Motififard
No. 22, Roshd Ave., Daneshgah Blvd., Isfahan
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3337 7986 motififard@med.mui.ac.ir Esfahan University of Medical Sciences scientific Mehdi Motififard
No. 22, Roshd Ave., Daneshgah Blvd., Isfahan
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3337 7986 motififard@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Age over 18 years Candidate for unilateral TKA surgery due to primary osteoarthritis Satisfaction to participate in the study 18 years 80 years Both Failure to follow up and examine the patient's condition Death of the patient Having chronic diseases D86.86 Sarcoid arthropathy Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: Patients in this group are treated with two doses of 400 mg celecoxib alone before surgery and their pain will be assessed by analog visual criteria at 24, 48 and 72 hours after surgery. Intervention group 2: Patients in this group are treated with two doses of 300 mg of gabapentin alone before surgery and their pain will be assessed by visual analog criteria at 24, 48 and 72 hours after surgery. Intervention group 3: Patients in this group, in addition to 400 mg celecoxib, are treated with two doses of 300 mg gabapentin before surgery and their pain will be assessed by visual analog criteria at 24, 48 and 72 hours after surgery. Intervention group 4: Patients in this group, in addition to celecoxib 400 mg and gabapentin 300 mg, will also receive two doses of dexamethasone 4 mg before surgery and their pain will be assessed by visual analog criteria at 24, 48 and 72 hours after surgery. Pain. Timepoint: 24, 48 and 72 hours after surgery. Method of measurement: Visual Analogue Scale. Esfahan University of Medical Sciences Approved 2021-01-13 Ethics committee of IsfahanUniversity of Medical Sciences Isfahan University of Medical Sciences, Hezar Jarib Ave., Isfahan Isfahan Isfehan Iran (Islamic Republic of)