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IRCT20120215009014N379 IRCT 2021-02-01 Hamedan University of Medical Sciences Effect of scaling and root surface correction with and without laser on gingival crevicular fluid cytokine levels in patients with chronic periodontitis Effect of scaling and root surface correction with and without laser on gingival crevicular fluid cytokine levels in patients with chronic periodontitis: a double-blind randomized clinical trial 2021-02-13 anticipated 15 Complete https://irct.ir/trial/54012 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random assignment of the right and left sides of the patients to the intervention and control groups through the drawing of lots. To do this, we prepare two sheets and write "right" on one sheet and "left" on another. Then, by referring to every patient, one of the sheets will be randomly taken. According to whether the sheet is taken right or left is assigned to the intervention group and the other side to the control group, Blinding description: The use of the laser as the main intervention on one side of the patient's mouth and not using it on the opposite side will be done simultaneously thus the patient will not be aware which part of the mouth will be affected by the laser. The physician who will examine the patients will not be aware of the intervention. .Thus, the trial will be run as double-blind. N/A Chronic periodontitis. Intervention 1: Intervention group: On one side of the patient, scaling and root surface correction by a piezoelectric scaling machine with a sharp pen plus laser Cr;YSGG Er with a head of RFTP5 with 1.5 W and 30 hz with angle less than 15 degree parallel to the tooth axis for 10 minutes. Intervention 2: Control group: On the other side of the patient, scaling and root surface correction by a piezoelectric scaling machine with a sharp pen. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situations and the results of the study as well as the approval of the financial supporting organization.
public Sahar Hemmatian
School of Dentistry, Hamadan University of Medical Sciences, Shahid Fahmideh Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3838 0572 sahar.hemmatian@gmail.com Hamedan University of Medical Sciences scientific Dr. Janet Moradi
School of Dentistry, Hamadan University of Medical Sciences, Shahid Fahmideh Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3838 0572 Janet_haghgoo@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Age of 20 to 65 years, Chronic periodontitis, Packet depth of 4 to 7 mm without destruction of angular bone, 20 years 65 years Both Pregnancy or breastfeeding, Generalized moderate to severe chronic periodontitis, Chronic liver or renal diseases or diabetes, Using tobacco K05.3 Chronic periodontitis Treatment - Other Other Intervention group: On one side of the patient, scaling and root surface correction by a piezoelectric scaling machine with a sharp pen plus laser Cr;YSGG Er with a head of RFTP5 with 1.5 W and 30 hz with angle less than 15 degree parallel to the tooth axis for 10 minutes Control group: On the other side of the patient, scaling and root surface correction by a piezoelectric scaling machine with a sharp pen Gingival crevicular fluid cytokine IL-1B levels. Timepoint: Before the intervention and 3 months later. Method of measurement: Using Elisa test. Hamedan University of Medical Sciences Approved 2020-12-19 Ethics Committee of Hamadan University of Medical Sciences Vice-chancellor for Research and Technology, Hamadan University of Medical Sciences, Shahid Fahmideh Ave Hamadan Hamadan Iran (Islamic Republic of)