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IRCT20210202050231N1 IRCT 2021-07-08 Zanjan University of Medical Sciences Comparison of the effect of vanilla essential oil with eucalyptus essential oil on the return of olfactory sense in COVID-19 patients Comparison of the effect of vanilla essential oil with eucalyptus essential oil on the return of olfactory sense in COVID-19 patients with olfactory dysfunction 2021-04-30 anticipated 84 Complete https://irct.ir/trial/54081 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: After selecting the available people, randomly blocked blocks with a volume of "6 random blocks" will be randomly assigned to one of the intervention and control groups, the list of blocks and their random order by the statistical consultant and based on Proc PLAN in software The SAS software will be identified and made available to the patient selector.In the proc command we will defined the total number of required samples, number of blocks, number of groups, code related to arm. so, output of SAS includes the code of participants in blocks with size 6, in each block, 2 samples regarding to each group are randomly distributed, Blinding description: Participants in the control group will receive a placebo. Statistical consultants are unaware of intervention and control groups. 3 covid-19. Intervention 1: Intervention group 1: Patients in this group have olfactory stimulation (sniffing 100% pure eucalyptus essential oil from the French company seven star) in plastic perfume bottles of 2.5 ml with the label "Do not eat" How to use: irritating smell for a week, every day 6 times (within 4 hours) after washing your nose with saline 0.9 percent. Intervention 2: Intervention group 2: Patients in this group have olfactory stimulation (smelling 100% pure vanilla essential oil from the French company sevenstar) in 2.5 ml plastic perfume containers labeled "Do not eat" How to use: Odor stimulation will be done 6 times a day (4 hours apart) after rinsing your nose with 0.9% rinsing serum. Intervention 3: Control group: Patients in this group will receive placebo (plastic perfume containers containing 2.5 ml of water labeled "Do not eat" for 6 weeks (every 4 hours) after rinsing the nose with serum Wash percentage). Yes - There is a plan to make this available What will be shared: All study information except personal information of the participants When: A year after the publication To whom: For researchers working in academic and scientific institutions Conditions: To extract more findings Where to obtain: By e-mail after the permission of the University of Medical Sciences How to obtain: Obtain permission from Zanjan University of Medical Sciences, email it to the person in charge of research, receive information Comments:
public Mohamad ali Yadegary
Zanjan School of Nursing and Midwifery
Zanjan Iran (Islamic Republic of) 4513956113 +98 24 3314 8241 ma.yadegary@gmail.com Zanjan University of Medical Sciences scientific Mohamad ali Yadegary
Zanjan School of Nursing and Midwifery
Zanjan Iran (Islamic Republic of) 4513956113 +98 24 3314 8241 ma.yadegary@gmail.com Zanjan University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Having informed consent to participate in the study - Have a positive PCR test They did not experience any signs of decreased olfactory and taste sensation at least 2 weeks before the onset of the first Covid-19 demonstrations. -Living in the city Non-smoker 18 years no limit Both - People with certain underlying diseases (such as asthma and history of allergies, Parkinson's, Alzheimer's, severe eating disorders, acute rhinitis, acute sinusitis, nasal congestion, for example, after rhinoplasty, traumatic nerve damage and. Having other viral and bacterial infections at the same time as Covid-19 - People who deal with thick odors in their job, such as working with paint or acid. U07.1 Coronavirus infection, unspecified site (B34.2)Coronavirus as the cause of diseases classified to other chapters (B97.2)Severe acute respiratory syndrome [SARS], unspecified (U04.9) Rehabilitation Rehabilitation Rehabilitation Intervention group 1: Patients in this group have olfactory stimulation (sniffing 100% pure eucalyptus essential oil from the French company seven star) in plastic perfume bottles of 2.5 ml with the label "Do not eat" How to use: irritating smell for a week, every day 6 times (within 4 hours) after washing your nose with saline 0.9 percent. Intervention group 2: Patients in this group have olfactory stimulation (smelling 100% pure vanilla essential oil from the French company sevenstar) in 2.5 ml plastic perfume containers labeled "Do not eat" How to use: Odor stimulation will be done 6 times a day (4 hours apart) after rinsing your nose with 0.9% rinsing serum. Control group: Patients in this group will receive placebo (plastic perfume containers containing 2.5 ml of water labeled "Do not eat" for 6 weeks (every 4 hours) after rinsing the nose with serum Wash percentage) The result of the olfactory test is reported as a number from zero to 24 and indicates the function of the sense of smell in the range of normal and mild normosemia, anosmia, hyposemia (microsaemia). Timepoint: Before intervention, one week after intervention, two weeks after intervention. Method of measurement: University of Pennsylvania Odor Detection Test (UPSIT). Zanjan University of Medical Sciences Approved 2021-04-24 Ethics committee of zanjan university of medical sciences Professor Yousef Sabouti Blvd., Zanjan University of Medical Sciences zanjan Zanjan Iran (Islamic Republic of)