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IRCT20210127050156N1 IRCT 2021-03-03 Karaj University of Medical Sciences Comparison of the effect of vaginal progesterone on uterine Doppler findings in early-onset preeclampsia Comparison of the effect of vaginal progesterone on uterine Doppler findings in early-onset preeclampsia 2021-03-20 anticipated 80 Complete https://irct.ir/trial/54095 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: First, this study is done as a pilot, and then, based on the results, the sample size is determined. Simple randomization approach will be implemented in this study. Randomization will be performed using a computer-generated list. For this purpose, 80 sealed ‎envelopes will be numbered 1-80 according to the randomization list. Group allocation ‎will be kept separate until the study is completed. The randomization ratio would be 1: 1, with 40 ‎envelopes allocated to each group, Blinding description: Completion of the final information is up to the person who is unaware of the type of treatment and also the specialist will be blind. Due to the type of intervention, participants are aware of the type of treatment. 3 Preeclampsia. Intervention 1: Intervention group: Progesterone vaginal suppository 200 mg (Aburaihan pharmaceutical company) every night for one week. Intervention 2: Control group: Without intervention. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is not yet known if there will be a plan to make this available
public Masoomeh Farahani
Kamali hospital; Kamali alley; Shohada square; Shahid Beheshti street
Karaj Iran (Islamic Republic of) 3149779453 +98 26 3222 2021 m.farahanii@abzums.ac.ir Karaj University of Medical Sciences scientific Masoomeh Farahani
Kamali hospital; Kamali alley; Shohada square; Shahid Beheshti street
Karaj Iran (Islamic Republic of) 3149779453 +98 26 3222 2021 m.farahanii@abzums.ac.ir Karaj University of Medical Sciences Iran (Islamic Republic of) gestational age between 24-32 weeks Increased uterine artery resistance Single pregnancy Patients with a history of lupus antiphospholipid syndrome History of high blood pressure Previous history of preeclampsia Diabetic no limit no limit Female Having kidney, liver and heart disease Having progesterone sensitivity Having severe preeclampsia Rupture of membrance Patients with cardiomyopathy; Evidence of fetal growth retardation; Ultrasound evidence of life-threatening congenital anomalies Use assisted reproductive techniques such as IVF O14 Pre-eclampsia Treatment - Drugs N/A Intervention group: Progesterone vaginal suppository 200 mg (Aburaihan pharmaceutical company) every night for one week Control group: Without intervention Uterine artery resistance. Timepoint: Before and one week after the intervention. Method of measurement: Doppler ultrasound. Symptoms of preeclampsia. Timepoint: During pregnancy. Method of measurement: Doctor's opinion. Karaj University of Medical Sciences Approved 2020-11-21 Ethics committee of Alborz University of Medical Sciences Ethics committee unit; Vice Chancellor for Research; No.20; Saffarian alley; 45 Metri Golshahr street Tehran Tehran Iran (Islamic Republic of)