]>
IRCT20161204031229N6 IRCT 2022-03-23 Iran University of Medical Sciences The effect of magnesium sulfate in reducing the pain of knee replacement surgery The Effect of Magnesium Sulphate on Postoperative Pain and Opioid Consumption in Total knee arthroplasty 2021-05-22 anticipated 50 Complete https://irct.ir/trial/54098 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Block randomization (quadruple blocks) All possible blocks are arranged as follows: block 1: ABAB block 2: AABB block 3: ABBA block 4: BBAA block 5: BABA block 6: BAAB We need 15 blocks to select 60 people. We randomly select these blocks from the numbers 1 to 6.Using R software, we choose a random number between the numbers 1 to 6. For example, number 6 is chosen as the first block and number 2 as the forth block. The people who enter the study are given B-A-A-BA- A-B-B, respectively. Finally, group A receives control intervention and group B receives treatment intervention, Blinding description: The researcher is unaware that the medicine given to the patient is the main medicine or placebo. The participant (patient) is also unaware that the medicine being given to them is the main medicine or placebo. 3 Total knee arthroplasty. Intervention 1: Intervention group: 4 g of magnesium sulfate (equivalent to 8 cc of 50% magnesium sulfate) in 250 cc of normal saline was infused 30 minutes before the operation, during the operation and up to 2 hours after the operation. Intervention 2: Control group: 8 cc and 250 cc normal saline (by infusion with the same volume as the magnesium group) were given 30 minutes before the operation, during the operation and up to 2 hours after the operation. Yes - There is a plan to make this available What will be shared: The main consequence When: Access period starts 6 months after the results are published To whom: Researchers working in academic institutions Conditions: Total data Where to obtain: Email: aepharm@gmail.com How to obtain: by Email Comments:
public Azadeh Eshraghi
Tehran - Sattar Khan - st. Prayer - Corner of Mansouri Street - Hazrat Rasool Akram Hospital
Tehran Iran (Islamic Republic of) 1449614535 +98 21 6435 2564 aepharm@gmail.com Iran University of Medical Sciences scientific Azadeh Eshraghi
Tehran - Sattar Khan - st. Prayer - Corner of Mansouri Street - Hazrat Rasool Akram Hospital
Tehran Iran (Islamic Republic of) 1449614535 +98 21 6435 2564 aepharm@gmail.com Iran University of Medical Sciences Iran (Islamic Republic of) All volunteers for Total knee arthroplasty 18 years 75 years Both Diabetes Renal Disorder Hepatic Disorder Consumption of Calcium Blocker agents Consumption of Magnesium supplements before the study Consumption of Magnesium supplements during the study in the last month magnesium level more than 2.8 Pregnancy Lactation M17 Osteoarthritis of knee Rehabilitation Rehabilitation Intervention group: 4 g of magnesium sulfate (equivalent to 8 cc of 50% magnesium sulfate) in 250 cc of normal saline was infused 30 minutes before the operation, during the operation and up to 2 hours after the operation. Control group: 8 cc and 250 cc normal saline (by infusion with the same volume as the magnesium group) were given 30 minutes before the operation, during the operation and up to 2 hours after the operation. Evaluate the patient's pain. Timepoint: Immediately after surgery, 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Use visual analogue scale and numerical rating scale. Serum level of magnesium sulfate. Timepoint: Daily. Method of measurement: Laboratory methods. Iran University of Medical Sciences Approved 2021-01-04 Ethics Committee of Iran University of Medical Sciences Tehran, Hemmat Highway next to Milad Tower, Iran University of Medical Sciences Tehran Tehran Iran (Islamic Republic of)