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IRCT20141009019470N116 IRCT 2021-04-13 Shiraz University of Medical Sciences Comparison effects of intravenous and local lidocain and remifentanil on hemodynamic changes during tracheal intubatin in hypertensive patients Comparison effects of intravenous and local lidocain and remifentanil on hemodynamic changes during tracheal intubatin in hypertensive patients 2021-04-18 anticipated 90 Complete https://irct.ir/trial/54153 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: By simple randomization and number extraction in triplicate blocks from www.sealedenvelope.com and an anesthesia nurse who has no role in the study will divide patients into three groups one, two and three, Blinding description: Patients do not know the type of group assignment. In order to blind the anesthesiologist who is in charge of collecting data, an anesthesiologist who is aware of the conditions of study and grouping of patients, prepares the drugs and gives them to the anesthesiologist and the anesthesiologist is not aware of the type of drug in the syringe. In all three groups, patients receive an intravenous injection and a topical drug administration to the vocal cords and epiglottis. 2-3 hypertension. Intervention 1: Intervention group: Two similar 10 cc syringes marked with labels A and B. Syringe A containing 1.5 mg / kg lidocaine diluted to 10 cc for spraying with nelaton catheter on the vocal cords and epiglottis and B syringe containing 10 cc Distilled water for intravenous injection. Intervention 2: Intervention group: Two similar 10 cc syringes marked with labels A and B. Syringe A containing 10 cc of distilled water for spraying with a nalton catheter on the vocal cords and epiglottis and syringe B containing 10 cc of lidocaine 1.5 mg / ml Diluted kg for intravenous injection. Intervention 3: Intervention group: Two similar 10 cc syringes marked with labels A and B. Syringe A containing 10 cc of distilled water for spraying with a nalton catheter on the vocal cords and epiglottis and syringe B containing remifentanil 1 μg / kg diluted to 10 cc for intravenous injection. No - There is not a plan to make this available Justification or reason for not sharing IPD is It is against the policies of our center.
public Nushin Reza Alizadeh
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 3647 4270 nushin.alizadeh@gmail.com Shiraz University of Medical Sciences scientific Seyed Mohammad Hadavi
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) 7134844119 +98 917 123 1237 Hadavimr@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Patients over 18 years ASA 2-3 Uncontrolled blood pressure Patients who are candidate for elective surgery under general anesthesia with endotracheal tube 18 years no limit Both Patients who are hypersensitive to any of the drugs lidocaine or remifentanil Patients who need rapid sequence induction Mallampati 3,4 Difficult intubation Consumption of beta blocker Patients who need to receive antihypertensive medication due to a significant increase in blood pressure during surgery I10 Essential (primary) hypertension Prevention Prevention Prevention Intervention group: Two similar 10 cc syringes marked with labels A and B. Syringe A containing 1.5 mg / kg lidocaine diluted to 10 cc for spraying with nelaton catheter on the vocal cords and epiglottis and B syringe containing 10 cc Distilled water for intravenous injection. Intervention group: Two similar 10 cc syringes marked with labels A and B. Syringe A containing 10 cc of distilled water for spraying with a nalton catheter on the vocal cords and epiglottis and syringe B containing 10 cc of lidocaine 1.5 mg / ml Diluted kg for intravenous injection. Intervention group: Two similar 10 cc syringes marked with labels A and B. Syringe A containing 10 cc of distilled water for spraying with a nalton catheter on the vocal cords and epiglottis and syringe B containing remifentanil 1 μg / kg diluted to 10 cc for intravenous injection. Blood pressure. Timepoint: After endotracheal intubation and after removal. Method of measurement: monitoring. Heart rate changes. Timepoint: After endotracheal intubation and after removal. Method of measurement: monitoring. آریتمی قلبی. Timepoint: After endotracheal intubation and after removal. Method of measurement: monitoring. Shiraz University of Medical Sciences Approved 2020-12-13 Ethics committee of Shiraz University of Medical Sciences Vice chancellor of research,7th floor of central building of Shiraz University of Medical Sciences, Zand street Shiraz Fars Iran (Islamic Republic of)