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IRCT20141209020258N151 IRCT 2021-02-21 Arak University of Medical Sciences Comparison of hemodynamic and antiemetic effects of midazolam combination with three drugs , ephedrine, dexamethasone and dexmedetomidine in patients undergoing laparoscopic cholecystectomy Comparison of hemodynamic and antiemetic effects of midazolam combination with three drugs , ephedrine, dexamethasone and dexmedetomidine in patients undergoing laparoscopic cholecystectomy 2021-03-05 anticipated 96 Complete https://irct.ir/trial/54405 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple individual randomization with random allocation with envelopes in 2 groups A and B and C. In this method, we selected a number of cards or letters as an intervention group and the same ‎number of cards for the control group, then the cards were merged. One card was taken out and its ‎allocation was registered and the card was returned to the other cards after leaving. Then the cards ‎are merged again and we remove another card. This process continues to reach a random sequence ‎according to sample size, Blinding description: This study is clinical trial.Outcome elevator and analyzer and participant are blind (double blind).Outcome elevator and analyzer and participant don't aware from grouping. 2-3 cholecystectomy. Intervention 1: Intervention group 1: 0.5 mg / kg ephedrine will be prescribed. (Made by Biotica Pharmaceutical Company). Intervention 2: Intervention group 2: 0.05 mg / kg dexamethasone will be prescribed. (Caspian Tamin Company, Rasht - Iran). Intervention 3: Intervention group 3: 1 mcg / kg dexmedetomidin will be prescribed. (Exir - Iran). Yes - There is a plan to make this available What will be shared: When we publish article in journal When: After the article is published To whom: Researcher in university Conditions: If there are additional questions Where to obtain: Dr Hesamodin Modir How to obtain: Correspondence should be made with professors and universities. Comments:
public Dr Hesamedin Modir
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 modir.he@gmail.com Arak University of Medical Sciences scientific Dr Hesamedin Modir
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 modir.he@gmail.com Arak University of Medical Sciences Iran (Islamic Republic of) Candidate patients for laparoscopic cholecystectomy ASA class 1 and 2 No history of mental illness and psychosis No Parkinson's disease, motion sickness or history of chemotherapy Patients under general anesthesia Duration of surgery 60 to 150 minutes Lack of sensitivity to the drugs used No hypertension and no vascular problems 18 years 60 years Both Patients without conscious consent Death of the patient K91.86 Retained cholelithiasis following cholecystectomy Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: 0.5 mg / kg ephedrine will be prescribed. (Made by Biotica Pharmaceutical Company) Intervention group 2: 0.05 mg / kg dexamethasone will be prescribed. (Caspian Tamin Company, Rasht - Iran) Intervention group 3: 1 mcg / kg dexmedetomidin will be prescribed. (Exir - Iran) Incidence of nausea. Timepoint: Recovery and 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Observation. Vomiting. Timepoint: Up to 24 hours after surgery. Method of measurement: Score 0 to 4. Severe nausea. Timepoint: Up to 24 hours after surgery. Method of measurement: Visual analog scale. Sedation. Timepoint: In recovery and 1, 2 and 4 hours after surgery. Method of measurement: Ramsay score. Arak University of Medical Sciences Approved 2021-01-24 Ethics comittee of Arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)