IRCT20160523028008N12 IRCT 2021-02-25 Shahid Beheshti University of Medical Sciences The effect of antibiotics on reducing infection Evaluation of the effect of oral metronidazole and cefixime as prophylaxis in uncomplicated appendicitis in comparison with ceftriaxone and metronidazole injection 2021-04-20 anticipated 200 Complete https://irct.ir/trial/54419 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients will be randomly assigned to intervention and control groups using block randomization. For this purpose, we will prepare four sheets of paper, writing on two sheets the name of the intervention and on the other two sheets the name of the control. The paper sheets will be pooled, placed in a container, and randomly drawn one at a time for each patient without replacement until all four sheets are drawn. The four paper sheets will be then placed back into the container, and this action repeated until the sample size is reached. 2-3 Acute appendicitis. Intervention 1: Intervention group: Metronidazole 500 mg with cefixime 400 mg orally. Intervention 2: Control group:Metronidazole 500 mg and one gram of ceftriaxone both injectable. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is not a plan to make this available