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IRCT20160307026950N32 IRCT 2021-03-07 Esfahan University of Medical Sciences The effect of Metoclopramide and Ondansetron on Etomidate injection pain Comparison of the efficacy of Metoclopramide and Ondansetron on altering the pain of Etomidate injection under general anesthesia 2021-04-04 anticipated 90 Complete https://irct.ir/trial/54635 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization is done in a simple way; In this way, the eligible patients enter groups B, A and C, respectively, depending on the time of their arrival, and this sequence is repeated until the number of patients reaches 30 in each group, Blinding description: This is a two-blind study in which the clinical caregiver and the person injecting the drug are different from the person performing the intervention and are unaware of the intervention. Also, patients in each group are explained that in order to reduce the pain caused by Types of intervention are applied to them without explaining the type of intervention. Therefore, patients are not aware of the type of intervention and are kept blind. 3 Pain due to Etomidate injection. Intervention 1: Intervention group A: Patients in this group after receiving the surgical bed and monitoring connection receive 10 mg of Metoclopramide and 10 minutes later 5 ml of distilled water, then Etomidate is injected and the patient's pain is measured immediately. Intervention 2: Intervention group B: Patients in this group after receiving the surgical bed and monitoring connection receive 10 mg of Metoclopramide and 10 minutes later 5 ml of distilled water, then Etomidate is injected and the patient's pain is measured immediately. Intervention 3: Control group C: Patients in this group receive 5 ml of distilled water after being placed on a surgical bed and monitoring connection and 5 minutes later receive 5 ml of distilled water, then Etomidate is injected and the patient's pain is measured immediately. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Ziba Zekavat
Hezar Jarib
Isfahan Iran (Islamic Republic of) 8146713543 +98 31 3620 2020 behzad_nazem@med.mui.ac.ir Esfahan University of Medical Sciences scientific Behzad Nazem roaya
Hezar Jarib
Isfahan Iran (Islamic Republic of) 8146713543 +98 31 3620 2020 behzad_nazem@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Aged 18 to 65 years criteria Anesthesia grade 1 and 2 according to ASA (American society Anesthesia) Candidates for elective surgery and Require general anesthesia with atomiditis 18 years 65 years Both Allergy to the Etomidate Allergy to the Metocloramide Allergy to the Ondansetrone Prevention Prevention Placebo Intervention group A: Patients in this group after receiving the surgical bed and monitoring connection receive 10 mg of Metoclopramide and 10 minutes later 5 ml of distilled water, then Etomidate is injected and the patient's pain is measured immediately. Intervention group B: Patients in this group after receiving the surgical bed and monitoring connection receive 10 mg of Metoclopramide and 10 minutes later 5 ml of distilled water, then Etomidate is injected and the patient's pain is measured immediately. Control group C: Patients in this group receive 5 ml of distilled water after being placed on a surgical bed and monitoring connection and 5 minutes later receive 5 ml of distilled water, then Etomidate is injected and the patient's pain is measured immediately. Pain due to atomeditis injection. Timepoint: Immediately after the intervention. Method of measurement: By scoring with VAS (visual analog scale) from 1 (painless) to 2 (worst pain imaginable). Vice Chancellor for Research, Isfahan University of Medical Sciences Approved 2020-08-11 Isfahan University of Medical Sciences Committe for Ethics in Biomedical Research Hezar Jarib St Isfahan Isfehan Iran (Islamic Republic of)