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IRCT20100102002963N32 IRCT 2021-06-12 Azad Islamic University Of Yazd Effect of intravenous Esmolol and intravenous Lidocaine on hemodynamic variables during laryngoscopy and tracheal intubation and postoperative nausea and vomiting Comparison of the effect of intravenous Esmolol and intravenous Lidocaine on hemodynamic variables during laryngoscopy and tracheal intubation and postoperative nausea and vomiting in patients undergoing abdominal surgery 2021-06-06 anticipated 64 Complete https://irct.ir/trial/54779 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In order to randomly allocate 64 eligible applicants, we randomly divide them into two groups of 32 people. For this purpose, we use Random allocation software version 1.0 under Windows to creat sequence, and by using this software we make A list which is specified from 1 to 64 with group A or B treatment By using this list, we give the first oerson who is eligible to enter the study, number 1 and the last person the number 64, then based on the random allocation list and by the software, it is determinded which group A or B each person is in, Blinding description: Only patients are unaware of how to group and the amount and type of medication used It is necessary to mention in this research the drugs used and Their levels in both experimental groups are completely routine and tested The only side effects of the drug from the time of injection of the drug until the end of its effect and Nausea and vomiting are assessed in two groups and recorded if they occur. 2-3 Comparison of the effect of intravenous osmolol and intravenous lidocaine on hemodynamic variables during laryngoscopy and tracheal intubation and postoperative nausea and vomiting in patients undergoing abdominal surgery. Intervention 1: Intervention group 1: In this group, 0.5 mg/kg of Esmolol, from Myungmoon pharmaceutical Co., Ltd is injected intravenously and once immediately before induction of general anesthesia to eligible patients. Intervention 2: Intervention group 2: In this group, lidocaine 1.5 mg per kg body weight of the patient, from Caspian tamin company is injected intravenously and once immediately before induction of general anesthesia to eligible patients. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Dr. Shekoufeh Behdad
Shahid Sadoughi Hospital, Ebnesina Blv, Safayieh, Yazd
YAZD Iran (Islamic Republic of) 8915887857 +98 35 3822 4101 behdad90@gmail.com Yazd University of Medical Sciences scientific Dr Shekofeh Behdad
Shahid Sadoughi Hospital, Ebnesina Blv, Safayieh, Yazd
YAZD Iran (Islamic Republic of) 8915887857 +98 35 3822 4101 behdad90@gmail.com Yazd University of Medical Sciences Iran (Islamic Republic of) All female patients are candidates for gynecological abdominal surgery 25 years 65 years Female Arterial hypertension Ischemic heart disease Heart failure Pulmonary disease Addiction Renal disease Liver disease Treatment - Drugs Treatment - Drugs Intervention group 1: In this group, 0.5 mg/kg of Esmolol, from Myungmoon pharmaceutical Co., Ltd is injected intravenously and once immediately before induction of general anesthesia to eligible patients. Intervention group 2: In this group, lidocaine 1.5 mg per kg body weight of the patient, from Caspian tamin company is injected intravenously and once immediately before induction of general anesthesia to eligible patients. Changes in systolic blood pressure. Timepoint: Immediately before drug injection immediately before laryngoscopy immediately after endotracheal intubation immediately after skin incision. Method of measurement: Operating room monitoring with Blood pressure cuff connected to the monitor and recording information in a questionnaire. Determining and comparing the incidence of bradycardia ( heart rate <50 ). Timepoint: Immediately after the operation in recovery room. Method of measurement: Monitoring in the recovery room with a blood pressure monitor connected to the monitor and recording information in a questionnaire. Determining and comparing the incidence of vomiting and nausea. Timepoint: Immediately after the operation in recovery room. Method of measurement: Question from the patient and registration in the questionnaire. Changes in diastolic blood pressure. Timepoint: Immediately before drug injection Immediately before laryngoscopy Immediately after endothracheal intubation Immediately after skin incision. Method of measurement: Operating room monitoring with Blood pressure cuff connected to the monitor and recording information in a questionnaire. Changes in mean arterial blood pressure. Timepoint: Immediately before drug injection Immediately before laryngoscopy Immediately after intubation Immediately after skin incision. Method of measurement: Operating room monitoring with Blood pressure cuff connected to the monitor and recording infirmation in a questionnaire. Changes in heart rates. Timepoint: Immediately before drug injection Immediately before laryngoscoy Immediately after endothracheal intubation Immediately after skin incision. Method of measurement: Operating room monitoring with Blood pressure cuff connected to the monitor and recording information in a questionnaire. Determining and comparing the incidence of hypotension side effects ( systolic blood pressure <9 ) or drop of more than 20% of the base rate. Timepoint: Immediately after the operation in recovery room. Method of measurement: Monitoring in the recovery room with a blood pressure monitor connected to the monitor and recording information in a questionnaire. Azad Islamic University Of Yazd Approved 2020-08-09 Ethics Committee of Ali Ibn Abi Talib Medical School (AS), Islamic Azad University, Yazd Branch Safaieh, Boulevard of the Shohadaie Gomnam YAZD Yazd Iran (Islamic Republic of)