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IRCT20170326033146N6 IRCT 2021-04-08 Razi University The effect of acetazolamide on athletic performance at height Effect of acetazolamide on exercise performance of male physical education students in simulated altitude 2021-04-21 anticipated 14 Complete https://irct.ir/trial/54862 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Prevention, Randomization description: Block randomization Someone other than the researchers will use the random allocation software for the allocation of the subjects by a randomized blocking method. During the process of allocation, each subject will be given a unique identification code that will be given to the main researchers together with the necessary treatment (Acetazolamide or placebo). The identification code will be used as a label to identify the group of each subject for data analysis after completion of the study. The random allocation software program can generate block randomization. The sample size and the name of the two groups (Acetazolamide and placebo) will be defined in the randomization main menu of the software. Then, the block design will be entered as equal size. Also, the format of the unique identification code will be defined as alphanumeric with fixed length. The last step is to generate the random list in which each entry in the list consists of a unique identification code and a group name, Blinding description: Because this study is double-blind, the subjects and researchers will not know who take acetazolamide or placebo, and someone else will assess the results. Also, medications will be prepared in the similar capsules, and the placebo group will use lactose powder. 3 Hypoxia. Intervention 1: Supplementary group: First, a cognitive function test will be performed. 48 hours later, subjects will take 2 doses of 125 mg and another dose the next morning of acetazolamide. The Astrand test will be then performed, and hypoxia will be induced immediately, and the test will be repeated. A one-week wash out period will be considered. Intervention 2: Placebo group: First, a cognitive function test will be performed. 48 hours later, subjects will take 2 doses of 125 mg and another dose the next morning. The Astrand test will be then performed, and hypoxia will be induced immediately, and the test will be repeated. A one-week wash out period will be considered. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Vahid Tadibi
School of Sports Sciences, Razi University, University Blvd., Taghe Bostan
Kermanshah Iran (Islamic Republic of) 6714414971 +98 83 3427 9265 vtadibi@yahoo.com Razi University scientific Vahid Tadibi
School of Sports Sciences, Razi University, University Blvd., Taghe Bostan
Kermanshah Iran (Islamic Republic of) 6714414971 +98 83 3427 9265 vtadibi@yahoo.com Razi University Iran (Islamic Republic of) Male student of Razi University 18 to 29 years old BMI: 18.5 - 29.4 18 years 29 years Male Permanent residence at altitudes above 2000 meters History of cognitive disorders or neurological diseases Having a chronic illness Smoking History of living at altitudes of more than 2000 meters in the two months before the start of a research Prevention Prevention Supplementary group: First, a cognitive function test will be performed. 48 hours later, subjects will take 2 doses of 125 mg and another dose the next morning of acetazolamide. The Astrand test will be then performed, and hypoxia will be induced immediately, and the test will be repeated. A one-week wash out period will be considered. Placebo group: First, a cognitive function test will be performed. 48 hours later, subjects will take 2 doses of 125 mg and another dose the next morning. The Astrand test will be then performed, and hypoxia will be induced immediately, and the test will be repeated. A one-week wash out period will be considered. Endurance training performance. Timepoint: The beginning of the study to assess the level of endurance function after taking acetazolamide or placebo and after hypoxia. Method of measurement: The Astrand test for men is used to measure the maximum power output of the subjects. Razi University Approved 2021-02-24 Ethics committee of Kermanshah Razi University Tagh-e-Bostan, University St. Kermanshah Kermanshah Iran (Islamic Republic of)