IRCT20150221021168N3 IRCT 2021-05-06 University of social welfare and rehabilitation sciences A Comparison of Adjunctive Quetiapine Versus Adjunctive Haloperidol in Combination with Sodium Valproate for Treatment of Patients with Bipolar I Disorder BQS A Comparison of Adjunctive Quetiapine Versus Adjunctive Haloperidol in Combination with Sodium Valproate for Treatment of Patients with Mania or Mixed Feature Bipolar I Disorder 2021-05-22 anticipated 40 Complete https://irct.ir/trial/54890 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random allocation software will be used for the randomization of two parallel groups in this trial . (https://www.randomization.com ), Blinding description: All parties of this clinical trial will remain unaware of the treatment allocation and grouping. Patients, investigators, and healthcare providers will be independent individuals and blinded to the treatment received by the patients. 3 Bipolar Mood Disorder with Mania or Mixed feature. Intervention 1: First Intervention group: Patients with bipolar 1 disorder with the most recent episode of mania or mixed feature Sodium Valproate 15 mg/kg/day and haloperidol 10 mg/day for 42 days or 6 weeks. Intervention 2: Second Intervention group: Patients with bipolar 1 disorder with the most recent episode of mania or mixed feature Sodium Valproate 15 mg/kg/day with Quetiapine 500mg/day for 42 days or 6 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is This measure depends on the results of the research and the study patients' agreements .