IRCT20210117050057N2 IRCT 2021-03-19 Magrabi Eye, ENT and Dental Center, Doha, Qatar Comparison of the Effects of Dexmedetomidine and Fentanyl-Midazolam Combination on Mitigating Stress Response for Microlaryngoscopy Comparison of the Effects of Dexmedetomidine and Fentanyl-Midazolam Combination on Mitigating Stress Response for Microlaryngoscopy: A Randomized, Double-Blind, Clinical Trial 2021-03-25 anticipated 60 Complete https://irct.ir/trial/54925 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients will be randomly assigned to one of two groups using computer-generated software of randomization introduced into sealed opaque envelops which are sequentially numbered, Blinding description: An independent nurse, who did not participate in the study or data collection prepared all study drugs. These drugs were administered by another nurse who was blind to the study and the groups. The anesthesiologist, surgeon and data collectors were all blinded to the given study drugs and the envelops were opened immediately before administration by a person who did not participate in the observation. 2-3 Microlaryngoscopy. Intervention 1: Dexmedetomidine group: 30 patients who received 1 µg/kg of dexmedetomidine over 10 minutes before anesthesia induction followed by 0.05 mg/kg/h as infusion after anesthesia induction. Intervention 2: Fentanyl-Midazolam group: 30 patients received fentanyl 0.8 µg/kg plus midazolam 0.05 mg/kg over 10 minutes before anesthesia induction followed by 1 µg/kg/h fentanyl and 0.05 mg/kg/h midazolam as infusion after anesthesia induction. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is not yet known if there will be a plan to make this available